A5092102825- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- Medicinal Plants and Bioactive Compounds
- Bacterial biofilms and quorum sensing
- Bacterial Genetics and Biotechnology
- Bacteriophages and microbial interactions
- RNA modifications and cancer
- Toxoplasma gondii Research Studies
- Dialysis and Renal Disease Management
- Advanced Glycation End Products research
- Circadian rhythm and melatonin
- interferon and immune responses
- RNA and protein synthesis mechanisms
- Circular RNAs in diseases
- Neurological Disease Mechanisms and Treatments
- Biological and pharmacological studies of plants
- Antibiotic Resistance in Bacteria
Wuhan University
2024
Zhongnan Hospital of Wuhan University
2024
University Hospital Regensburg
2023
Ferroptosis is involved in ischemia and reperfusion injury (IRI) of transplanted kidney. Understanding the molecular mechanisms ferroptosis essential to elucidate pathogenesis IRI. 1307 differentially expressed genes (DEGs) were obtained by GSE90861 retrieved from GEO database. 29 ferroptosis-related DEGs intersection with FerrDb database, which subjected enrichment analysis cytoHubba plugin for selecting top three (IL6, ATF3 JUN) as hub genes. Next, ROC showed good diagnostic prospects both...
To explore the change of clock gene rhythm under renal denervation (RDN) and its effect on function oxidative stress during ischemia-reperfusion (IR) injury.C57/BL6 mice were randomly divided into 4 groups at daytime 7 A M (zeitgeber time [ZT] 0) or nighttime P (ZT12) in respectively: Sham (S) group, RDN IR group + (DIR) group. Renal pathological functional changes assessed by H&E staining, serum creatinine, urea nitrogen neutrophil gelatinase-associated lipocalin levels. was detected SOD...
The choline–glycine betaine pathway plays an important role in bacterial survival hyperosmotic environments. Osmotic activation of the choline transporter BetT promotes uptake external for synthesizing osmoprotective glycine betaine. Here, we report cryo–electron microscopy structures Pseudomonas syringae apo and choline-bound states. Our structure shows that forms a domain-swapped trimer with C-terminal domain (CTD) one protomer interacting transmembrane (TMD) neighboring protomer....