A5035275912- Migraine and Headache Studies
- Computational Drug Discovery Methods
- Bioinformatics and Genomic Networks
- Biofuel production and bioconversion
- Epigenetics and DNA Methylation
- Enzyme Production and Characterization
- Studies on Chitinases and Chitosanases
- Gene Regulatory Network Analysis
- Health, Environment, Cognitive Aging
- Aquaculture disease management and microbiota
- Enterobacteriaceae and Cronobacter Research
- Microbial infections and disease research
- Plant Virus Research Studies
- Genetic Syndromes and Imprinting
- Seismology and Earthquake Studies
- Environmental Toxicology and Ecotoxicology
- Tannin, Tannase and Anticancer Activities
- Earthquake Detection and Analysis
- earthquake and tectonic studies
- Genetic Associations and Epidemiology
- Neuroscience of respiration and sleep
- Pesticide Exposure and Toxicity
- Gene expression and cancer classification
- Metabolism, Diabetes, and Cancer
Queensland University of Technology
2023
COMSATS University Islamabad
2010-2020
Migraine-a painful, throbbing headache disorder-is the most common complex brain disorder, yet its molecular mechanisms remain unclear. Genome-wide association studies (GWAS) have proven successful in identifying migraine risk loci; however, much work remains to identify causal variants and genes. In this paper, we compared three transcriptome-wide study (TWAS) imputation models-MASHR, elastic net, SMultiXcan-to characterise established genome-wide significant (GWS) GWAS loci, putative novel...
The identification of pathogenically-relevant genes and tissues for complex traits can be a difficult task. We developed an approach named genome-wide imputed differential expression enrichment (GIDEE), to prioritise trait-relevant by combining association study (GWAS) summary statistic data with tissue-specific quantitative trait loci (eQTL) from 49 GTEx tissues. Our GIDEE analyses robustly gene tests differentially expressed in each tissue. Two (mean squared z-score empirical Brown's...
Pest management in stored grain industry is a global issue due to the development of insecticide resistance insect pests. Excessive use insecticides at higher doses poses serious threat food contamination and residual toxicity for consumers. Since new pesticide incurs heavy costs, identifying an effective synergist can provide ready economical tool controlling resistant pest populations. Therefore, synergistic property quercetin with paraoxon tetraethyl pyrophosphate has been evaluated...
Adenosine-Monophosphate-Activated protein kinase (AMPK) is a conserved that plays an important role in maintaining the homeostasis of cells. AMPK activation has positive impact on treatment diseases such as diabetes, obesity and cancer well. This observation led to development activators. Certain naturally occurring compounds have also been known activate AMPK.In this study, we retrieved activators include chemical drugs, xenobiotics natural analyzed their interactions with via docking...
Recent work has demonstrated the effectiveness of using complex networks for studying biological interactions. The process often involves conversion data such as gene expressions or biochemical interactions into one numerous network file formats. However, exact selection an appropriate format a particular dataset poses non-trivial decision problem, biologists are non-specialist end-users and find it difficult to select storage conversion. In this paper, we propose solution problem suitable...