A5067827124- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- Mass Spectrometry Techniques and Applications
- Advanced Radiotherapy Techniques
- Molecular Biology Techniques and Applications
- Virus-based gene therapy research
Purdue University West Lafayette
2024
Vanderbilt University Medical Center
2010
Objective. The volume of subcutaneous xenograft tumors is an important metric disease progression and response to therapy in preclinical drug development. Noninvasive imaging technologies suitable for measuring are increasingly available, yet manual calipers, which susceptible inaccuracy bias, routinely used. goal this study was quantify compare the accuracy, precision, inter-rater variability tumor assessment by caliper measurements ultrasound imaging. Methods. Subcutaneous derived from...
G-quadruplex (G4) DNA can form highly stable secondary structures in the presence of metal cations, and research has shown its potential as a transcriptional regulator for oncogenes human genome. In order to explore interactions with cations using mass spectrometry, employing complementary fragmentation methods enhance structural information. This study explores use ion–ion reactions sequential negative electron transfer collision-induced dissociation (nET-CID) complement traditional...