A5038323449- Sphingolipid Metabolism and Signaling
- Erythrocyte Function and Pathophysiology
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Cellular transport and secretion
- Lipid Membrane Structure and Behavior
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- RNA modifications and cancer
- Pharmacological Effects and Toxicity Studies
Bayer (Germany)
2023-2025
University Hospital Cologne
2020
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
2020
University of Cologne
2020
Sphingosine-1-phosphate (S1P) is a signaling lysolipid critical to heart development, immunity, and hearing. Accordingly, mutations in the S1P transporter SPNS2 are associated with reduced white cell count hearing defects. also exports S1P-mimicking FTY720-P (Fingolimod) thereby central pharmacokinetics of this drug when treating multiple sclerosis. Here, we use combination cryo-electron microscopy, immunofluorescence, vitro binding vivo export assays, molecular dynamics simulations probe...
Ferroptosis is a form of regulated necrosis characterized by chain-reaction detrimental membrane lipid peroxidation following collapse glutathione peroxidase 4 (Gpx4) activity. This catalyzed labile ferric iron. Therefore, iron import mediated via transferrin receptors and both, enzymatic non-enzymatic iron-dependent radical formation are crucial prerequisites for the execution ferroptosis. Intriguingly, dynamin inhibitor dynasore, which has been shown to block receptor endocytosis, can...
With over 450 genes, solute carriers (SLCs) constitute the largest transporter superfamily responsible for uptake and efflux of nutrients, metabolites, xenobiotics in human cells. SLCs are associated with a wide variety diseases, including cancer, diabetes, metabolic neurological disorders. They represent an important therapeutic target class that remains only partly exploited as therapeutics scarce. Additionally, many small molecules reported literature to poorly characterized. Both...
Abstract Sphingosine-1-phosphate (S1P) is a signaling lysolipid critical to heart development, immunity, and hearing. Accordingly, mutations in the S1P transporter SPNS2 are associated with reduced white cell count hearing defects. also exports S1P-mimicking FTY720-P (Fingolimod) thereby central pharmacokinetics of this drug when treating multiple sclerosis. Here, we use combination cryo-electron microscopy, immunofluorescence, vitro binding vivo export assays, molecular dynamic simulations...