A5046214259- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Single-cell and spatial transcriptomics
- vaccines and immunoinformatics approaches
- Immune Cell Function and Interaction
Institute of Bioorganic Chemistry
2017
The ability to decode antigen specificities encapsulated in the sequences of rearranged T-cell receptor (TCR) genes is critical for our understanding adaptive immune system and promises significant advances field translational medicine. Recent developments high-throughput sequencing methods (immune repertoire technology, or RepSeq) single-cell RNA technology have allowed us obtain huge numbers TCR from donor samples link them phenotypes. However, annotate these still lags behind, owing...
Adaptive immune responses to newly encountered pathogens depend on the mobilization of antigen-specific clonotypes from a vastly diverse pool naive T cells. Using recent advances in repertoire sequencing technologies, models receptor rearrangement process, and database annotated cell (TCR) sequences with known specificities, we explored baseline frequencies cells specific for defined human leukocyte antigen (HLA) class I-restricted epitopes healthy individuals. We used TCR specificities...