A5068082982- Antimicrobial Peptides and Activities
- Polydiacetylene-based materials and applications
- Lipid Membrane Structure and Behavior
- Advanced biosensing and bioanalysis techniques
- biodegradable polymer synthesis and properties
- Mitochondrial Function and Pathology
- Nanoparticle-Based Drug Delivery
- Polysaccharides Composition and Applications
- Protein Hydrolysis and Bioactive Peptides
- Pharmaceutical and Antibiotic Environmental Impacts
- Pediatric health and respiratory diseases
- Silk-based biomaterials and applications
- Nanopore and Nanochannel Transport Studies
- Advanced Nanomaterials in Catalysis
- Molecular Junctions and Nanostructures
- Tracheal and airway disorders
- Chemical and Environmental Engineering Research
- Protein Interaction Studies and Fluorescence Analysis
- Respiratory and Cough-Related Research
Institut polytechnique de Grenoble
2021
VetAgro Sup
2021
Université Grenoble Alpes
2021
Centre National de la Recherche Scientifique
2021
Institut Laue-Langevin
2021
Klinik für Schlafmedizin
2004
Abstract This study explores the coating of photocatalytic nanoparticles with antimicrobial peptides (AMPs) for boosted effects, and how such effects depend on AMP properties. For this, TiO 2 are coated KYE21 or its hydrophobically enhanced variant WWWKYE21. Mirroring free peptides, displayed higher binding UV‐induced degradation bacteria‐like than mammalian‐like membranes. In addition, they degraded bacterial lipopolysaccharides (LPS). WWWKYE21‐coated to LPS membranes degradation, although...
The Bcl-2 family of proteins control mitochondrial outer membrane (MOM) pore formation, crucial to cellular clearance via apoptosis. However, the molecular principles by which opposing members inhibit, mediate or promote MOM perforation remain elusive. Here, we demonstrate that cell-protecting directly sequesters cell-killing Bax into a protein-protein complex at interface preventing forming apoptotic pores. Neutron reflectometry showed association with occurs through formation protein...
This study explores coating of photocatalytic nanoparticles with antimicrobial peptides (AMPs) for boosted effects, and how such effects depend on AMP properties. For this, TiO2 were coated the KYE21 or its hydrophobically enhanced variant WWWKYE21. Mirroring free peptides, displayed higher binding UV-induced degradation bacteria-like than mammalian-like membranes. In addition, they degraded bacterial lipopolysaccharides (LPS). Among WWWKYE21-coated nanoparticle to both LPS membranes, as...
Conformationally controlled amphiphilicity of antimicrobial peptides affects their ability to coat photocatalytic TiO 2 nanoparticles (NPs) and controls membrane interactions peptide-coated NPs, boosting effects.
In this study, we report the degradation of smooth and rough lipopolysaccharides (LPS) from Gram-negative bacteria lipoteichoic acid (LTA) Gram-positive by peptide-coated TiO2 nanoparticles (TiO2 NPs). While bare NPs displayed minor binding to both LPS LTA, coating with antimicrobial peptide LL-37 dramatically increased level decorating these uniformly. Importantly, did not suppress reactive oxygen species generation NPs; hence, UV illumination triggered pronounced LTA NPs. Structural...
In the present study, we investigated degradation of both smooth and rough lipopolysaccharides from Gram-negative (LPS) lipoteichoic acid Gram-positive (LTA) bacteria by peptide-coated TiO2 nanoparticles (TiO2 NPs). While bare NPs displayed minor binding to LPS LTA, coating with antimicrobial peptide LL-37 dramatically increased decorating these uniformly. Importantly, did not suppress reactive oxygen species generation NPs, hence UV illumination triggered pronounced LTA NPs. Structural...
A key to the development of lipid membrane-based devices is a fundamental understanding how molecular structure bilayer membrane influenced by type lipids used build membrane. This particularly important when proteins are included in these since precise environment affects ability incorporate and their functionality. Here, we neutron reflectometry investigate tethered membranes characterize incorporation NhaA sodium proton exchanger bilayer. The were composed two lipids, dioleoyl...
Wir untersuchten das Vorkommen von Mikroorganismen im Sputum, induziertem Sputum und in der Bronchiallavage bei 1.387 Patienten mit Atemwegserkrankungen einem Durchschnittsalter (X±SD) 65,1±15,9 Jahren. Insgesamt wurden 10.470 Proben untersucht ausgewertet. Folgende Häufigkeiten bezogen auf die Gesamtzahl (n) anteilmäßig (in %) nachgewiesen. Keime Normalflora: 5,1%. Normalflora pathogene Keime: 77,3%. Dazu gehörten Rachenflora (n=594; 42,8%), Gram positive Mischflora (n=371; 26,8%)...