About
Contact & Profiles
A5104687501
Research Areas
- Heat shock proteins research
- Tendon Structure and Treatment
- Cellular Mechanics and Interactions
Pontificia Universidad Católica de Chile
2024
Abstract Force transmission through adherens junctions (AJs) is crucial for multicellular organization, wound healing and tissue regeneration. Recent studies shed light on the molecular mechanisms of mechanotransduction at AJs. However, canonical model fails to explain force when essential proteins module are mutated or missing. Here, we demonstrate that, in absence α-catenin, β-catenin can directly functionally interact with vinculin its open conformation, bearing physiological forces....
10.1038/s41467-024-49850-5
article
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cc-by
Nature Communications
2024-07-05
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