A5035294857- Skin Protection and Aging
- melanin and skin pigmentation
- Telomeres, Telomerase, and Senescence
- Antioxidant Activity and Oxidative Stress
- RNA regulation and disease
- Animal Genetics and Reproduction
- Biochemical Analysis and Sensing Techniques
- Silk-based biomaterials and applications
- Cutaneous Melanoma Detection and Management
- CRISPR and Genetic Engineering
- Extracellular vesicles in disease
- Genomics and Chromatin Dynamics
- Wnt/β-catenin signaling in development and cancer
- Toxin Mechanisms and Immunotoxins
- Olfactory and Sensory Function Studies
- Hair Growth and Disorders
- Transgenic Plants and Applications
- Melanoma and MAPK Pathways
- PI3K/AKT/mTOR signaling in cancer
- Body Image and Dysmorphia Studies
Centre National de la Recherche Scientifique
2011-2024
Université Paris Sciences et Lettres
2017-2024
Institut Curie
2011-2024
Université Paris-Saclay
2017-2024
Galderma (United States)
2024
Inserm
2011-2017
La Ligue Contre le Cancer
2017
There is increasing evidence that senescent cells are a driving force behind many age-related pathologies and their selective elimination increases the life- healthspan of mice. Senescent negatively affect surrounding tissue by losing cell specific functionality secreting pro-tumorigenic pro-inflammatory mixture growth hormones, chemokines, cytokines proteases, termed senescence-associated secretory phenotype (SASP). Here we identified an extract from plant Solidago virgaurea subsp....
MITF-M and PAX3 are proteins central to the establishment transformation of melanocyte lineage. They control various cellular mechanisms, including migration proliferation. BRN2 is a POU domain transcription factor expressed in melanoma cell lines involved proliferation invasion, at least part by regulating expression PAX3. The T361 S362 residues BRN2, both domain, conserved throughout protein family targets for phosphorylation, but their roles vivo remain unknown. To examine role this we...
Sestrin 2 (SESN2) is an evolutionarily conserved regulator of mechanistic target rapamycin complex 1 (mTORC1) which controls central cellular processes such as protein translation and autophagy. Previous studies have suggested that SESN2 itself subjected to regulation at multiple levels. Here, we investigated the expression in skin isolated cells. was detected by immunofluorescence analysis fibroblasts keratinocytes human skin. Differentiation epidermal not associated with altered...
Abstract The exposure of skin to ultraviolet ( UV ) radiation can have both beneficial and deleterious effects: it lead, for instance, increased pigmentation vitamin D synthesis but also inflammation cancer. UVB may induce genetic epigenetic alterations reversible effects associated with post‐translational gene regulation modifications. β‐catenin is a main driver in melanocyte development; although infrequently mutated melanoma, its cellular localization activity are frequently altered....
Many studies on melanocyte biology have gathered a great deal of knowledge the genetic and developmental mechanisms driving skin hair pigmentation. The first coat colour genetics date from early 1900s when mouse pigmentation mutants were used to test Mendelian theories describe linkage analyses in vertebrates (Castle, 1903; Haldane et al., 1915). In addition information genetics, interest melanocytes was amplified by their transformation formation melanoma, an aggressive often lethal type...
Melanocytes are dendritic cells that produce melanin, the natural pigment responsible for colour of skin, eyes, hair and skin appendages. Melanin synthesis, as brown/black eumelanin red/yellow pheomelanin, occurs within a specialized lysosome-like structure called melanosome (Orlow, 1995). Pigment synthesis by melanocytes not only produces extensive complex coloration patterns seen in mammals, but also protects against potentially harmful effects light, absorbing scattering light reducing...
ABSTRACT Ultraviolet (UV) rays prompt a natural response in epidermal cells, particularly within melanocytes. The changes gene expression and related signaling pathways melanocytes following exposure to UV radiation are still not entirely understood. Our findings reveal that UVB irradiation suppresses the of Dicer (also known as Dicer1). This repression is intricately linked activation phosphoinositide 3-kinase (PI3K), ribosomal S6 kinase (RSK) Wnt–β-catenin pathways, directly associated...
ABSTRACT Ultraviolet (UV) rays prompt a natural response in epidermal cells, particularly within melanocytes. The changes gene expression and related signaling pathways melanocytes following exposure to UVR are still not entirely understood. Our findings reveal that UVB irradiation suppresses the of Dicer. This repression is intricately linked activation PI3K, RSK, WNT/β-catenin directly associated with transcriptional by β-catenin. Notably, we have identified specific binding sites for...