Abstract Metal‐catalyzed chain‐walking reactions have recently emerged as a powerful strategy to functionalize remote positions in organic molecules. However, protocol for nonconjugated dienes remains scarcely reported, and developments are currently ongoing. In this Communication, nickel‐catalyzed asymmetric hydrocyanation of involving process is demonstrated. The reaction exhibits excellent regio‐ chemoselectivity, wide range substrates were tolerated, delivering the products high yields...

Abstract The asymmetric Reppe carbonylation reactions provide a straightforward access to α ‐chiral carbonyl compounds. reported paradigms predominantly adopted precious palladium as the catalyst. Here we report nickel‐catalyzed of cyclopropenes with phenyl formate and CO/ROH, respectively. This asymmetrical synthetic protocol features high atom economy, good functional group tolerance, which rapidly constructs polysubstituted cyclopropanecarboxylic derivatives excellent diastereo‐...

A new triazolopyrimidine derivative, namely, 6-hydroxy-7-phenyl-6,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one (HPTP) was synthesized. Its corrosion inhibition performance on mild steel in 1 M HCl solution researched through weight loss, potentiodynamic polarization (PDP), electrochemical impedance spectroscopy (EIS), and scanning electron microscope (SEM) approaches. The experimental results show that the efficiency of HPTP increases with increase concentrations, whereas decreases as...

Abstract A regiodivergent nickel‐catalyzed hydrocyanation of a broad range internal alkenes involving chain‐walking process is reported. When appropriate diastereomeric biaryl diphosphite ligands are applied, the same starting materials can be converted to either linear or branched nitriles with good yields and high regioselectivities. DFT calculations suggested that catalyst architecture determines regioselectivity by modulating electronic steric interactions. In addition, moderate...

Abstract Enantioselective auto‐tandem catalysis represents a challenging yet highlight attractive topic in the field of asymmetric catalysis. In this context, we describe dual catalytic cycle that merges allylic cyanation and hydrocyanation. The one‐pot conversion broad array alcohols into their corresponding 1,3‐dinitriles proceeds good yield with high enantioselectivity. products are densely functionalized can be easily transformed to chiral diamines, dinitriles, diesters, piperidines....

A new route to phosphines was developed by a method that features “pre-join and transform” process proceeds via acylphosphine intermediates may be readily prepared from carboxylic acids disubstituted phosphines. The efficient decarbonylations of these acylphosphines using nickel catalyst delivered the corresponding This shows carboxyl group can play role similar halides or triflates for introducing substituted phosphorus atom on an aromatic ring.

A vast range of novel TADDOL-based diphosphite ligands were first synthesized and applied in the nickel-catalyzed asymmetric hydrocyanation disubstituted methylenecyclopropanes. By employing these new catalysts, conversion diverse methylenecyclopropanes into their corresponding allylic nitriles was enabled, good yield with excellent enantioselectivities.

An imidazolium-based ionic liquid, i.e., 1-Hexadecyl-3-methylimidazolium Bromide (HMIBr), was investigated as a corrosion inhibitor candidate for mild steel in 1 M HCl medium using combined electro ...

A regio-, chemo-, and enantioselective nickel-catalyzed hydrocyanation of 1,3-dienes is reported. The key to the success this asymmetric transformation use a specific multichiral diphosphite ligand. In addition aryl-substituted 1,3-dienes, highly challenging aliphatic 1,3-diene substrates can also be preferentially converted corresponding 1,2-adducts in decent yields with highest enantioselectivities date.

The Markovnikov hydrocyanation of α-substituted styrenes enables the synthesis tertiary benzylic nitriles under nickel catalysis. Lewis-acid-free transformation features an unprecedented functional groups tolerance, including −OH and −NH2 groups. A broad range were obtained in good to excellent yields. In addition, asymmetric version this reaction was preliminarily investigated.

Abstract Metal‐catalyzed chain‐walking reactions have recently emerged as a powerful strategy to functionalize remote positions in organic molecules. However, protocol for nonconjugated dienes remains scarcely reported, and developments are currently ongoing. In this Communication, nickel‐catalyzed asymmetric hydrocyanation of involving process is demonstrated. The reaction exhibits excellent regio‐ chemoselectivity, wide range substrates were tolerated, delivering the products high yields...

Palladium-catalyzed C–P bond formation reaction of ArBr/ArOTf using acylphosphines as differential phosphination reagents is reported. The show practicable reactivity with ArBr and ArOTf the reagents, though they are inert to air moisture. affords trivalent phosphines directly in good yields a broad substrate scope functional group tolerance. This discloses acylphosphines' capability new phosphorus sources for direct synthesis phosphines.

Hydrothiocarbonylation of olefins using carbon monoxide and thiols is a powerful method to synthesize thioesters from simple building blocks. Owing the intrinsic challenges catalyst poisoning, transition-metal-catalyzed asymmetric thiocarbonylation, particularly when utilizing earth abundant metals, remains rare in literature. Herein, we report nickel-catalyzed enantioselective hydrothiocarbonylation cyclopropenes for synthesis diverse collection functionalized good excellent yields with...

Abstract A regiodivergent nickel‐catalyzed hydrocyanation of a broad range internal alkenes involving chain‐walking process is reported. When appropriate diastereomeric biaryl diphosphite ligands are applied, the same starting materials can be converted to either linear or branched nitriles with good yields and high regioselectivities. DFT calculations suggested that catalyst architecture determines regioselectivity by modulating electronic steric interactions. In addition, moderate...

Abstract The asymmetric Reppe carbonylation reactions provide a straightforward access to α ‐chiral carbonyl compounds. reported paradigms predominantly adopted precious palladium as the catalyst. Here we report nickel‐catalyzed of cyclopropenes with phenyl formate and CO/ROH, respectively. This asymmetrical synthetic protocol features high atom economy, good functional group tolerance, which rapidly constructs polysubstituted cyclopropanecarboxylic derivatives excellent diastereo‐...

We herein develop a highly diastereoselective synthesis of cyano-substituted cyclopropanes via palladium-catalyzed direct cyanoesterification cyclopropenes, which features mild reaction conditions, good functional group compatibility, and simple operation. This transformation represents stepwise, atom economic, scalable protocol for obtaining synthetically useful cyclopropanecarbonitriles.

Abstract Enantioselective auto‐tandem catalysis represents a challenging yet highlight attractive topic in the field of asymmetric catalysis. In this context, we describe dual catalytic cycle that merges allylic cyanation and hydrocyanation. The one‐pot conversion broad array alcohols into their corresponding 1,3‐dinitriles proceeds good yield with high enantioselectivity. products are densely functionalized can be easily transformed to chiral diamines, dinitriles, diesters, piperidines....

Novel regioselective hydrodeoxygenation of α-diketones with phosphites as the deoxygenation reagent was realized via visible-light photoredox catalysis. Broad substrate scope and high functional group compatibility were obtained. Unsymmetric selectively reduced at carbonyls higher electrophilicity. This unique regioselectivity compared available methods makes it a practical complementary approach for monohydrodeoxygenation α-diketones.

A highly regioselective nickel-based catalyst system for the isomerization/hydrocyanation of aliphatic internal olefins is described. This benign tandem reaction provides facile access to a wide variety nitriles in good yields with excellent regioselectivities. Thanks Lewis acid-free conditions, protocol features board functional groups tolerance, including secondary amine and unprotected alcohol groups.

Due to the multifaceted reactivities of cyclopropenes, divergent hydrofunctionalization these compounds has recently attracted significant attention. Herein, we present a Pd-catalyzed hydrocyanation cyclopropenes via aluminum Lewis acid-controlled...

The inhibition effect of a triazolopyrimidine derivative, i.e., 6-hydroxy-5-phenyl-5,6-dihydro-[1,2,4]tria zolo[4,3-a]pyrimidin-7(8H)-one (HPDTP), against the corrosion mild steel in 1 M HCl solution was investigated by electrochemical test. We find that efficiency increases with inhibitor concentration and it attains an more than 90% at 10−3 M. Polarization curves show HPDTP is mix-type inhibitor. Changes impedance parameters were indicative adsorption on surface, leading to formation...