A5036969478- Genetic and Kidney Cyst Diseases
- Virus-based gene therapy research
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Viral-associated cancers and disorders
- Ovarian cancer diagnosis and treatment
- Plant tissue culture and regeneration
- Cancer-related molecular mechanisms research
- Hepatocellular Carcinoma Treatment and Prognosis
- Animal Virus Infections Studies
- Transgenic Plants and Applications
- Endometrial and Cervical Cancer Treatments
- Cancer, Lipids, and Metabolism
- Hepatitis Viruses Studies and Epidemiology
- Birth, Development, and Health
- Bone Tissue Engineering Materials
- Cancer Genomics and Diagnostics
- Gynecological conditions and treatments
- Satellite Communication Systems
- Organic Light-Emitting Diodes Research
- Ferroptosis and cancer prognosis
- Bone and Dental Protein Studies
- Opportunistic and Delay-Tolerant Networks
Johns Hopkins University
2023-2024
Sidney Kimmel Comprehensive Cancer Center
2024
National Taiwan University
2006-2022
Wan Fang Hospital
2019
Taipei Medical University
2019
China Medical University
2013
China Medical University Hospital
2013
Genomics Research Center, Academia Sinica
2011
Academia Sinica
2010
Faculty (United Kingdom)
2008
Serous tubal intraepithelial carcinoma (STIC) is the fallopian tube precursor lesion for most cases of pelvic high-grade serous (HGSC). To date, morphologic, molecular, and clinical heterogeneity STIC a less atypical putative lesion, termed has not been well characterized. Better understanding could impact management women with incidental STICs (without concurrent carcinoma) identified in prophylactic or opportunistic salpingectomy. This study analyzed morphologic molecular features 171 21...
Abstract Tubo-ovarian high-grade serous carcinoma is believed to originate in the fallopian tubes, arising from precursor lesions like tubal intraepithelial (STIC) and lesion (STIL). Adequate diagnosis of these precursors important, but can be challenging for pathologists. Here we present a deep-learning algorithm that could assist pathologists detecting STIC/STIL. A dataset STIC/STIL ( n = 323) controls 359) was collected split into three groups; training 169), internal test set 327),...
The avian eggshell primarily consists of calcium carbonate mineral (calcite) and matrix proteins. Here we review matrix-mineral relationships in the at ultrastructural level using scanning transmission electron microscopy, describe distribution osteopontin (OPN) as determined by colloidal gold immunolabeling for OPN. A rich protein network integrated within calcitic structure shows variable, region-specific organization that included layered fibrous planar sheets matrix, thin filamentous...
In the present study, authors compared long-term risk of nasopharyngeal carcinoma (NPC) male participants in an NPC multiplex family cohort with that controls a community Taiwan after adjustment for anti-Epstein-Barr virus (EBV) seromarkers and cigarette smoking. A total 43 incident cases were identified from 1,019 males 9,622 cohort, 8,061 person-years 185,587 person-years, respectively. The adjusted hazard ratio was 6.8 (95% confidence interval (CI): 2.3, 20.1) cohort. evaluation anti-EBV...
Abstract NUTM1 gene rearrangement is the genetic hallmark of NUT carcinoma, an aggressive tumor that most commonly affects thoracic and head neck regions often exhibits squamous differentiation. The common fusion partner BRD4 , followed by BRD3 NSD3 . Recently, has been identified in rare tumors from soft tissues, intracranial locations, other visceral organs. These show high grade malignant epithelioid to round cell histomorphology lack evidence and/or epithelial Therefore, their...
Abstract Purpose: Serous tubal intraepithelial carcinoma (STIC) is now recognized as the main precursor of ovarian high-grade serous (HGSC). Other potential lesions include p53 signatures and lesions. We aimed to investigate extent pattern aneuploidy in these epithelial HGSC define features that characterize stages tumor initiation progression. Experimental Design: applied RealSeqS compare genome-wide patterns among precursors, (cases, n = 85), histologically unremarkable fallopian tube...
<div>AbstractPurpose:<p>Serous tubal intraepithelial carcinoma (STIC) is now recognized as the main precursor of ovarian high-grade serous (HGSC). Other potential lesions include p53 signatures and lesions. We aimed to investigate extent pattern aneuploidy in these epithelial HGSC define features that characterize stages tumor initiation progression.</p>Experimental Design:<p>We applied RealSeqS compare genome-wide patterns among precursors, (cases,...
<p>The numbers of specimen subtypes included in the study.</p>
<p>Table cluster comparing the distribution of incidental active STIC to associated with HGSC according different aneuploidy groups.</p>
<p>Table cluster comparing the distribution of incidental active STIC to associated with HGSC according different aneuploidy groups.</p>
<p>Distribution of active STICs with CCNE1 and MYC/RECQL4 amplification.</p>
<p>Degree of aneuploidy between incidental active STIC and HGSC.</p>
<p>Degree of aneuploidy between incidental active STIC and HGSC.</p>
<p>Representative histology images of the lesions with discrepant pathology diagnosis and molecular classification.</p>
<div>AbstractPurpose:<p>Serous tubal intraepithelial carcinoma (STIC) is now recognized as the main precursor of ovarian high-grade serous (HGSC). Other potential lesions include p53 signatures and lesions. We aimed to investigate extent pattern aneuploidy in these epithelial HGSC define features that characterize stages tumor initiation progression.</p>Experimental Design:<p>We applied RealSeqS compare genome-wide patterns among precursors, (cases,...
<p>RealseqS data of all the lesions analyzed.</p>
<p>Table cluster determining correlation between STIC growth patterns and molecular classifications.</p>
<p>The information of antibodies used in the study.</p>
<p>RealseqS data of all the lesions analyzed.</p>
<p>Representative images of MT-CO1 loss regions and phenotype after knockdown.</p>
<p>Representative histology images of the lesions with discrepant pathology diagnosis and molecular classification.</p>
<p>Table cluster determining correlation between STIC growth patterns and molecular classifications.</p>