A5007174039- Genetic and Kidney Cyst Diseases
- Virus-based gene therapy research
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Animal Virus Infections Studies
- Testicular diseases and treatments
- Chromatin Remodeling and Cancer
- Cancer-related molecular mechanisms research
- Viral-associated cancers and disorders
- Cancer Genomics and Diagnostics
- Uterine Myomas and Treatments
- Gynecological conditions and treatments
- Metastasis and carcinoma case studies
Johns Hopkins University
2023-2025
Johns Hopkins Medicine
2025
Sibley Memorial Hospital
2023
Serous tubal intraepithelial carcinoma (STIC) is the fallopian tube precursor lesion for most cases of pelvic high-grade serous (HGSC). To date, morphologic, molecular, and clinical heterogeneity STIC a less atypical putative lesion, termed has not been well characterized. Better understanding could impact management women with incidental STICs (without concurrent carcinoma) identified in prophylactic or opportunistic salpingectomy. This study analyzed morphologic molecular features 171 21...
Carcinosarcoma with a mesonephric-like carcinomatous component (MLCS) is rare subtype of gynecologic malignancy recently described in the literature. This study aims to expand genomic characterization MLCS by performing independent molecular analysis and sarcomatous components series MLCS. Eight cases (endometrial, lower uterine segment, ovarian) were identified underwent clinicopathologic evaluation. Genomic DNA extraction next-generation sequencing (NGS) performed separately from 4 tumors,...
Abstract Tubo-ovarian high-grade serous carcinoma is believed to originate in the fallopian tubes, arising from precursor lesions like tubal intraepithelial (STIC) and lesion (STIL). Adequate diagnosis of these precursors important, but can be challenging for pathologists. Here we present a deep-learning algorithm that could assist pathologists detecting STIC/STIL. A dataset STIC/STIL ( n = 323) controls 359) was collected split into three groups; training 169), internal test set 327),...
Gynecologic yolk sac tumors (YSTs) are more commonly encountered in children and young women as pure or mixed germ cell rarely observed older women. YSTs sometimes accompanied by a Müllerian-type carcinoma component, indicating likely somatic rather than germ-cell origin. Studies of types this age group limited. Analysis additional with YST differentiation could elucidate differences between these tumor subtypes the relationship components tumors. Clinicopathologic features 32 malignant...
Abstract Purpose: Serous tubal intraepithelial carcinoma (STIC) is now recognized as the main precursor of ovarian high-grade serous (HGSC). Other potential lesions include p53 signatures and lesions. We aimed to investigate extent pattern aneuploidy in these epithelial HGSC define features that characterize stages tumor initiation progression. Experimental Design: applied RealSeqS compare genome-wide patterns among precursors, (cases, n = 85), histologically unremarkable fallopian tube...
<div>AbstractPurpose:<p>Serous tubal intraepithelial carcinoma (STIC) is now recognized as the main precursor of ovarian high-grade serous (HGSC). Other potential lesions include p53 signatures and lesions. We aimed to investigate extent pattern aneuploidy in these epithelial HGSC define features that characterize stages tumor initiation progression.</p>Experimental Design:<p>We applied RealSeqS compare genome-wide patterns among precursors, (cases,...
<p>The numbers of specimen subtypes included in the study.</p>
<p>Table cluster comparing the distribution of incidental active STIC to associated with HGSC according different aneuploidy groups.</p>
<p>Table cluster comparing the distribution of incidental active STIC to associated with HGSC according different aneuploidy groups.</p>
<p>Distribution of active STICs with CCNE1 and MYC/RECQL4 amplification.</p>
<p>Degree of aneuploidy between incidental active STIC and HGSC.</p>
<p>Degree of aneuploidy between incidental active STIC and HGSC.</p>
<p>Representative histology images of the lesions with discrepant pathology diagnosis and molecular classification.</p>
<div>AbstractPurpose:<p>Serous tubal intraepithelial carcinoma (STIC) is now recognized as the main precursor of ovarian high-grade serous (HGSC). Other potential lesions include p53 signatures and lesions. We aimed to investigate extent pattern aneuploidy in these epithelial HGSC define features that characterize stages tumor initiation progression.</p>Experimental Design:<p>We applied RealSeqS compare genome-wide patterns among precursors, (cases,...
<p>RealseqS data of all the lesions analyzed.</p>
<p>Table cluster determining correlation between STIC growth patterns and molecular classifications.</p>
<p>The information of antibodies used in the study.</p>
<p>RealseqS data of all the lesions analyzed.</p>
<p>Representative images of MT-CO1 loss regions and phenotype after knockdown.</p>
<p>Representative histology images of the lesions with discrepant pathology diagnosis and molecular classification.</p>
<p>Table cluster determining correlation between STIC growth patterns and molecular classifications.</p>
<p>Representative images of MT-CO1 loss regions and phenotype after knockdown.</p>
<p>Distribution of active STICs with CCNE1 and MYC/RECQL4 amplification.</p>
<p>The numbers of specimen subtypes included in the study.</p>