A5033172293- Pain Management and Opioid Use
- Pain Mechanisms and Treatments
- Pain Management and Placebo Effect
- Nausea and vomiting management
- Pediatric Pain Management Techniques
- Anesthesia and Pain Management
- Opioid Use Disorder Treatment
- Cancer Treatment and Pharmacology
- Musculoskeletal pain and rehabilitation
- Attention Deficit Hyperactivity Disorder
- Urinary Bladder and Prostate Research
- Analytical Methods in Pharmaceuticals
- Eicosanoids and Hypertension Pharmacology
- Asthma and respiratory diseases
- Nitric Oxide and Endothelin Effects
- Heart Rate Variability and Autonomic Control
- Urinary Tract Infections Management
- Bipolar Disorder and Treatment
- Pelvic floor disorders treatments
- Palliative Care and End-of-Life Issues
- Veterinary Pharmacology and Anesthesia
- Complementary and Alternative Medicine Studies
- Hormonal Regulation and Hypertension
- Inflammatory mediators and NSAID effects
- Cardiac electrophysiology and arrhythmias
Purdue Pharma (Canada)
1997-2010
Health Decisions (United States)
2008
University of Alberta
2006
University of Calgary
2005
Royal University Hospital
2004
Grey Nuns Community Hospital
1999
McGill University
1995
Montreal General Hospital
1995
Kelowna General Hospital
1994-1995
University of Kentucky
1995
PURPOSE Use of oxycodone for chronic cancer pain has been hampered by its short elimination half-life. This study was designed to compare the efficacy and safety controlled-release formulations morphine pain. PATIENTS AND METHODS Thirty-two adult patients with a > or = 3-day history stable analgesia oral opioids provided written informed consent were randomized 7 days. To blind using available tablet strengths, dose ratio set at 1:1.5. On day 8, crossed over alternate drug Pain intensity...
Treatment decisions for the use of opioid analgesics in chronic non-malignant pain are based primarily on survey data, as evidence from well-controlled clinical trials has been lacking. Forty-six patients with were enrolled a randomized, double-blind, placebo-controlled evaluation controlled-release (CR) codeine. Following 3-7-day diary familiarization period, randomly assigned to 7 days treatment each CR codeine q12h or placebo. The dose was determined consumption acetaminophen+codeine...
A group of 32 patients with moderately severe, chronic asthma (mean FEV1 55% predicted), maintained on high doses inhaled corticosteroids dose 1,100 micrograms/d), participated in this double-blind, placebo-controlled crossover study. The effect pulmonary function adding theophylline (U, once daily Uniphyl), salbutamol (S, 200 micrograms four times per day), and their combination (C) or placebo (P) was assessed Day 14 each treatment phase. Patients recorded peak expiratory flow, symptom...
OBJECTIVE: The present randomized, double‐blinded, crossover study compared the efficacy and safety of a seven‐day buprenorphine transdermal system (BTDS) placebo in patients with low back pain moderate or greater severity for at least six weeks. METHODS: Prestudy analgesics were discontinued evening before random assignment to 5 μg/h BTDS placebo, acetaminophen 300 mg/codeine 30 mg, one two tablets every 4 h 6 as needed, rescue analgesia. dose was titrated effect weekly, if tolerated, 10 20...
The present study was a randomized, parallel, double-blind comparison between controlled-release (CR) tramadol and sustained-release (SR) diclofenac in patients with chronic pain due to osteoarthritis of the hips and/or knees.
1 The inter‐relationships among oral isosorbide dinitrate (ISDN) dose, drug pharmacokinetics and pharmacological effects were studied in 12 angina patients following single chronic doses of 15, 30, 60 120 mg. 2 Significant accumulation intact ISDN plasma was observed after four times a day dosing at mg for week. 3 area under the concentration v time curve (AUC), form 0‐6 h, shown to be proportional dose doses. In contrast, AUC increased disproportionately dosing. 4 Pharmacokinetic correction...
1. Submaxillary gland blood flow and salivation have been measured in anaesthetized cats the chorda-lingual nerve has stimulated at different frequencies.2. At low stimulation frequencies (1-5 Hz) there was a large transient increase followed by more modest maintained which lasted as long continued. Stimulation 10-20 Hz also produced rapid initial but these subsequent decline not seen gradual further to level observed.3. Atropine small doses depressed both response frequency vasodilatation...
The short elimination half-life of hydromorphone necessitates 4-hourly dosing to maintain optimal levels analgesia in patients with chronic cancer pain. purpose this study was compare the clinical efficacy and safety controlled release administered every 12 hours immediate 4 severe pain.Forty-eight stable pain were randomized, a double-masked crossover study, or for 7 days each. Pain intensity assessed using visual analog scale (VAS) Present Intensity Index McGill Questionnaire. Nausea...
Background. The short elimination half-life of met-oclopramide necessitates frequent administration for optimal relief nausea. This study compares a newly developed controlled release preparation metoclopram-ide (CRM) and immediate metoclopramide (IRM) with respect to efficacy, safety, pharmacokinetics in patients chronic nausea associated advanced cancer. Methods. Thirty-four cancer lasting more than 1 month no evidence involvement the gastrointestinal tract, peptic ulcer or gastritis,...
Article Abstract Objective: To evaluate the efficacy and safety of a new biphasic multilayer-release (MLR) methylphenidate formulation in double-blind, placebo-controlled crossover study adults with attention-deficit/hyperactivity disorder (ADHD). Method: Adults 18 to 60 years age DSM-IV diagnosis ADHD entered no-medication baseline week were then randomly assigned once-daily MLR or matching placebo. Patients titrated optimal effect over 1 3 weeks followed by 2 treatment on stable dose. The...
Although the pharmacokinetics of oral hydromorphone has been evaluated in healthy volunteers after small single doses, data are not available regarding disposition and its principal metabolite, hydromorphone‐3‐glucuronide (H3G), at steady‐state large doses. The authors studied H3G administration an immediate‐release (IR) controlled‐release (CR) formulation a daily dose 48 ± 11 mg (range 6–216 mg) randomized, double‐blind, steady‐state, two‐way crossover evaluation 18 patients with chronic...
To determine the validity of pain intensity recall at 24 and 48 hours as a substitute for hourly assessments in repeated-dose analgesic studies.Orthopedic unit an acute care teaching hospital.Eighty-four patients undergoing arthroscopic reconstruction anterior cruciate ligament, using patellar tendon, who were participating randomized, double-blind, parallel-group study.Patients rated their every hour (while awake) worst, least, usual visual analog scale (VAS).This study examined...
To compare the efficacy and safety of controlled-release (CR) tramadol (Zytram XL, Purdue Pharma, Canada) placebo in patients with painful osteoarthritis.Patients underwent analgesic washout for two to seven days before random assignment 150 mg daily CR or placebo, were titrated weekly 200 mg, 300 a maximum 400 once daily. After four weeks, crossed over alternate treatment another weeks. Plain acetaminophen was provided as rescue analgesic. All who completed crossover study eligible receive...
PURPOSE A significant number of cancer patients will require an alternate route morphine administration at some point during their illness. This study compared the clinical efficacy and safety a novel sulfate controlled-release suppository (MS-CRS) subcutaneous (SC) in with pain. METHODS Thirty pain were randomized double-blind crossover to MS-CRS every 12 hours or SC 4 for days each, using 2.5:1 analgesic equivalence ratio. Pain intensity was assessed visual analog scale (VAS) Present...
Morphine-6-glucuronide is a metabolite of morphine that shows significant analgesic effects in animals and humans. To evaluate route-specific differences the potential contribution morphine-6-glucuronide to analgesia, we studied pharmacokinetics morphine, morphine-6-glucuronide, morphine-3-glucuronide after oral rectal administration sulfate six-subject randomized, single-dose, two-way crossover evaluation. The mean area under plasma concentration-time curve (AUC) molar ratios (M6G) (M3G)...