A5102858133- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Renal cell carcinoma treatment
- Renal and related cancers
- Inflammatory Biomarkers in Disease Prognosis
- Bladder and Urothelial Cancer Treatments
- Urologic and reproductive health conditions
- Urological Disorders and Treatments
- Cancer Genomics and Diagnostics
- Urinary and Genital Oncology Studies
- Urinary Bladder and Prostate Research
- MRI in cancer diagnosis
- Cancer, Lipids, and Metabolism
- Renal and Vascular Pathologies
- Colorectal Cancer Screening and Detection
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Genetic and Kidney Cyst Diseases
- Hormonal and reproductive studies
- Advanced MRI Techniques and Applications
- SARS-CoV-2 detection and testing
- Neurological Disorders and Treatments
- Clinical practice guidelines implementation
- Infectious Disease Case Reports and Treatments
- Social Media in Health Education
Nanjing Medical University
2023
Singapore General Hospital
2013-2022
Prostate Cancer Foundation
2021
Weatherford College
2021
Background Prognostic stratification is the cornerstone of management in nonmetastatic prostate cancer (PCa). However, existing prognostic models are inadequate—often using treatment outcomes rather than survival, stratifying by broad heterogeneous groups and heavily treated cohorts. To address this unmet need, we developed an individualised model that contextualises PCa-specific mortality (PCSM) against other cause mortality, estimates impact on survival. Methods findings Using records from...
Aims We hypothesised that CD1d expression in renal cell carcinoma (RCC) may play a role modifying the host immune response. Our aims were to investigate of and correlate this with histopathology clinical outcomes cohort study patients RCC. Methods Gene tissue microarray studies on panel RCC performed. Clinicopathological correlation was analysed using χ 2 /Fisher's exact test. Relapse-free survival, cancer-specific survival overall calculated for both high low expressors. Survival estimated...
To study the role of neutrophil-to-lymphocyte ratio in predicting survival outcomes for patients with advanced bladder cancer.We retrospectively reviewed 150 diagnosed or metastatic cancer between January 2004 and June 2014. The was computed on diagnosis after first cycle chemotherapy. A cut-off 3.0 determined, a concordance index 0.89. Kaplan-Meier curves, log-rank tests, Cox proportional hazards logistic regression models were used to predict association outcomes.Just five alive at end...
After radical prostatectomy (RP), one-third of patients will experience biochemical recurrence (BCR), which is associated with subsequent metastasis and cancer-specific mortality. We employed machine learning (ML) algorithms to predict BCR after RP, compare them traditional regression models nomograms.Utilizing a prospective Uro-oncology registry, 18 clinicopathological parameters 1130 consecutive who underwent RP (2009-2018) were recorded, yielding over 20,000 data points for analysis. The...
Objective To compare the detection rates of prostate cancer between systematic biopsy and targeted using a stereotactic robot‐assisted transperineal platform. Materials Methods We identified consecutive patients with suspicious lesion(s) on multiparametric magnetic resonance imaging (mpMRI), who underwent both MRI‐transrectal ultrasonography (US) fusion our proprietary platform January 2015 2019 at institution, for retrospective analysis. Comparative analysis was performed McNemar’s test,...
Men with benign prostate hyperplasia (BPH) good urinary flow may still have bladder outlet obstruction (BOO). Intravesical prostatic protrusion (IPP) has been shown to be able predict BOO. We aim investigate the use of IPP BOO in men flow.One hundred and fourteen consecutive (>50 years old) presenting lower tract symptoms suggestive BPH were recruited 2001 2002. They evaluated serum specific antigen (PSA), uroflowmetry transabdominal ultrasound measurement volume (PV). Pressure-flow...
The International Society of Urological Pathology made recommendations for the use Grade Groups (GG) originally described by Epstein and colleagues over Gleason score (GS) alone in 2014, which was subsequently adopted WHO classification 2016. majority studies validating this revision have been Caucasian populations. We therefore asked whether new GG system retrospectively associated with biochemical disease-free survival a mixed-ethnicity cohort Asian men.A total 680 radical prostatectomies...
To determine the role of neutrophil-to-lymphocyte ratio (NLR) in prognosticating survival outcomes patients with advanced/metastatic urothelial bladder cancer.We retrospectively reviewed 84 undergoing radical cystectomy (RC) for UCB from January 2002 to June 2012. NLR was computed (median: 5 days) prior surgery. No received neoadjuvant chemotherapy. analyzed as a continuous variable and cut-off point 2.7 obtained, statistical receiver operating characteristics 0.74. Kaplan-Meier curves,...
An elevated neutrophil-to-lymphocyte ratio (NLR) has been associated with adverse outcomes in various malignancies. However, its role prognosticating testicular cancer (TC) not validated. We aim to study the relationship between NLR and TC.We retrospectively reviewed 160 patients histological proven TC from January 2005 June 2016. Youden's index was used analyse a cut-off point of 3.0 obtained, statistical receiver operating characteristics 0.755. Chi-square test, Kaplan-Meier (log rank...
Objective. End-stage renal disease (ESRD) patients with acquired cystic kidney are at higher risk of developing cell carcinoma (RCC) than the general population. The aim this study was to investigate clinical and histopathological differences between ESRD population RCC. Materials methods. Data were retrospectively collected from all nephrectomies performed for localized RCC 2000 2010. Age nephrectomy, gender, race, symptoms, baseline Eastern Cooperative Oncology Group (ECOG) performance...
Objectives To compare the perioperative and oncological outcomes between robot‐assisted radical cystectomy with intracorporeal urinary diversion versus open for bladder cancer in a contemporary Enhanced Recovery After Surgery cohort. Methods All consecutive patients who underwent managed under an protocol, from December 2013 to October 2018, were reviewed. Propensity score adjustment was carried out reduce biases attributable covariate imbalances. Results There 19 21 patients. The cohort...
Objective To evaluate the incidence and management of local systemic complications afflicting patients with de novo metastatic prostate cancer (mPCa) in Singapore. Design Retrospective analysis a large prospective Uro-oncology registry mPCa. Setting This study is carried out tertiary hospital Participants We reviewed our institution’s prospectively maintained database 685 mPCa over 20-year period (1995–2014). Patients non-mPCa or those progressed to disease after previous curative treatments...
Objective To evaluate the prognostic values of perinephric fat invasion and renal vein in pT3a cell carcinoma, as stand‐alone factors combination with tumor size Fuhrman grade. Methods Survival data pT1 pT2 carcinomas were analyzed alongside tumors similar bands (pT1 vs <7 cm, >7 cm). Patients adjuvant therapy, positive surgical margins, metastasis or pT3b–pT4 excluded. Results No significant baseline demographic differences existed between groups. had larger (median, 7.2 ± 3.0 cm 5.5...
To validate the significance of entity "very-low-risk" bladder cancer by analyzing clinical outcomes low-risk when further stratified tumor size.We accessed our prospectively maintained, single-institution, electronic registry to extract clinicopathological data patients who were diagnosed with primary, solitary, Ta, low-grade tumors that <3 cm. Patients divided into two prognostic groups based on size (≤1.0 cm vs >1.0 cm). The survival compared for recurrence, progression and mortality.A...
Purpose: Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary disease, and 20% of patients eventually require nephrectomies due to compressive symptoms or renal-related complications.Traditionally, were performed via open approach in view space constraints.We evaluate our institution's outcomes for laparoscopic nephrectomy (LN) ADPKD.Materials Methods: We retrospectively reviewed 33 with ADPKD who underwent from November 2005 December 2016 at a tertiary...
We aimed to identify a prostate cancer DNA hypermethylation microarray signature (denoted as PHYMA) that differentiates from benign hyperplasia (BPH), high low-grade and lethal non-lethal cancers. This is non-randomized retrospective study in 111 local Asian men (87 cancers 24 BPH) treated 1995 2009 our institution. Archival epithelia were laser-capture microdissected genomic extracted bisulfite-converted. Samples profiled using Illumina GoldenGate Methylation microarray, with raw data...
Abstract Objective To evaluate if prostatic ductal adenocarcinoma (PDA) independently predicts poorer pathological and oncological outcomes after radical prostatectomy (RP). Methods Materials Utilizing a large prospective uro‐oncology registry, clinicopathological parameters of 1027 consecutive patients who underwent RP (2008–2017) were recorded. Oncological determined by failure to achieve unrecordable PSA postoperatively biochemical (BCF). Results PDA was present in 79 (7.7%) patients,...