A5049338860- Viral-associated cancers and disorders
- Histiocytic Disorders and Treatments
- Spinal Dysraphism and Malformations
- Lymphoma Diagnosis and Treatment
- Connective tissue disorders research
- NF-κB Signaling Pathways
- Bone fractures and treatments
- Teratomas and Epidermoid Cysts
- Cytomegalovirus and herpesvirus research
- Parvovirus B19 Infection Studies
- Fetal and Pediatric Neurological Disorders
- Bone health and treatments
Moorfields Eye Hospital NHS Foundation Trust
2011
University of Birmingham
1976-2010
Cancer Research UK
2009
Birmingham General Hospital
1976
Abstract Background The Epstein-Barr virus (EBV)-encoded EBNA1 protein is expressed in all EBV-associated tumours, including undifferentiated nasopharyngeal carcinoma (NPC), where it indispensable for viral replication, genome maintenance and gene expression. EBNA1's transcription factor-like functions also extend to influencing the expression of cellular genes involved pathways commonly dysregulated during oncogenesis, elevation AP-1 activity NPC cell lines resulting enhancement...
Kaposi's sarcoma-associated herpesvirus (KSHV) encodes four viral interferon regulatory factors (vIRF-1-4). We investigated the mechanism and consequences of vIRF-2-mediated inhibition interferon-response element signalling following type I (IFN) induction. Western blot electrophoretic mobility-shift assays identified interferon-stimulated gene factor-3 (ISGF-3) components STAT1 IRF-9 as proximal targets vIRF-2 activity. The biological significance ISGF-3 was demonstrated by rescue...
The case history, clinical course and laboratory findings in a 66-year-old woman with fibrogenesis imperfecta ossium are reported, the sixth literature. condition is characterized clinically by intractable skeletal pain progressive immobility. Though serum alkaline phosphatase has been raised all patients, there no specific haematological or biochemical findings. radiological features of coarse dense trabecular pattern symmetrical diffuse involvement bones without expansion change shape,...
White epidermoid cysts are rare intra-cranial lesions with an intrinsic brainstem location, though still rare. The location of the tumour poses radiological confusion and a therapeutic dilemma. Neuroimaging techniques like MRI diffusion tensor imaging (DTI) in this case proved useful tool ruling out other pathologies at certain morphologic similarities. findings indicated bilobed intra-axial lesion heterogenous signal intensities on T1 T2 weighted images. DTI showed splaying cortico-spinal...