A5038207495- DNA Repair Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Telomeres, Telomerase, and Senescence
- Carcinogens and Genotoxicity Assessment
- Nitric Oxide and Endothelin Effects
- Thyroid Cancer Diagnosis and Treatment
- RNA Research and Splicing
- Effects of Radiation Exposure
- Fungal and yeast genetics research
- Bone health and treatments
- Neuroscience of respiration and sleep
- Bioactive Compounds and Antitumor Agents
- Pituitary Gland Disorders and Treatments
- Nuclear Structure and Function
- RNA and protein synthesis mechanisms
- Evaluation Methods in Various Fields
- Multiple Myeloma Research and Treatments
- TGF-β signaling in diseases
- Bone health and osteoporosis research
- Thyroid and Parathyroid Surgery
- Genomics and Chromatin Dynamics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adrenal and Paraganglionic Tumors
- Estrogen and related hormone effects
- Genetic factors in colorectal cancer
Shaanxi Provincial People's Hospital
2024
Shanxi Medical University
2018-2020
Shaanxi Provincial People's Hospital
2018-2020
University of California, Irvine
2006-2010
National Institute for Radiological Protection
1993-2009
Computer Emergency Response Team
2009
Ministero della Salute
2009
Qingdao University
2008
University of California, San Francisco
2003-2004
La Jolla Institute for Immunology
2004
The CCR4-NOT complex (1 mDa in size), consisting of the proteins CCR4, CAF1, and NOT1 to NOT5, regulates gene expression both positively negatively is distinct from other large transcriptional complexes Saccharomyces cerevisiae such as SNF/SWI, TFIID, SAGA, RNA polymerase II holoenzyme. physical genetic interactions between components were investigated order gain insight into how this affects diverse genes processes. CAF1 protein was found be absolutely required for CCR4 association with NOT...
The POP2 (Caf1) protein in Saccharomyces cerevisiae affects a variety of transcriptional processes and is component the Ccr4p complex. We have isolated five multicopy suppressor genes pop2 deletion mutation: CCR4, DHH1 (a putative RNA helicase), PKC1, STM1, MPT5 (multicopy pop two). Overexpression either CCR4 or effectively suppressed phenotypes associated with mutant cells; overexpression produced only partial suppression. Disruption resulted similar to those observed for cells. In...
Forward genetic screens with ENU (N-ethyl-N-nitrosourea) mutagenesis can facilitate gene discovery, but mutation identification is often difficult. We present the first study in which an ENU-induced was identified by massively parallel DNA sequencing. This causes heterotaxy and complex congenital heart defects mapped to a 2.2-Mb interval on mouse chromosome 7. Massively sequencing of entire 2 single-base substitutions, one intergenic region second causing replacement highly conserved...
Estrogen receptor (ER)alpha and -beta interact with a variety of coactivator proteins, most notably members the steroid (SRC) family, these interactions have been shown to be regulated by estrogenic ligands growth factor signaling. Here, using fluorescence resonance energy transfer (FRET), selectivity different stimulants on ERalpha interaction domains (RIDs) were examined in living cells. We first show that ERbeta homo- heterodimers form vivo independently presence 17beta-estradiol (E2) or...
The objective of this study was to assess the radiation exposure levels in victims a (60)Co accident using chromosome aberration analysis and micronucleus assay. Peripheral blood samples were collected from three exposed 10 days after used for assays. After vitro culture lymphocytes, frequencies dicentric chromosomes rings (dic+r) numbers cytokinesis blocking micronuclei (CBMN) first mitotic division determined estimate dosimetry. Poisson distribution frequency dic+r lymphocytes uniformity...
<i>Background:</i> Chronic kidney disease (CKD) results in accelerated atherosclerosis and cardiovascular disease. This is primarily mediated by oxidative stress, inflammation dyslipidemia. By mediating reverse cholesterol transport exerting antioxidant/anti-inflammatory actions, high-density lipoprotein (HDL) ApoA-1 protect against atherosclerosis. Plasma Apo-1, HDL activities are reduced CKD. mimetic peptides associate with enhance properties of HDL. We hypothesized that...
Ectopic expression of telomerase results in an immortal phenotype various types normal cells, including primary human fibroblasts. In addition to its role telomere lengthening, has now been found have functions, the control DNA repair, chromatin modification, and genes involved cell cycle regulation. The investigations on long-term effects fibroblast highlighted that these cells show low frequencies chromosomal aberrations. this paper, we describe karyotypic stability fibroblasts...
<i>Background:</i> Single injection of small quantities phenol into the kidney cortex causes hypertension which is mediated by renal afferent sympathetic pathway activation. This phenomenon can be prevented superoxide dismutase (SOD) infusion in lateral ventricle, suggesting role (O<sub>2</sub><sup>–</sup>·¿ ) noradrenergic control arterial pressure. Since NAD(P)H oxidase a major source O<sub>2</sub><sup>–</sup>·¿ , we tested...
Background: 18 F-FDG PET and 131 I scans are important in the detection of metastases from differentiated thyroid carcinoma (DTC). The relationship FDG radioiodine (RAI) metabolism bone (BMs) DTC its prognostic value on RAI treatment is not clear. Methods: retrospective study included patients with BMs two medical centers, who underwent PET/CT therapy. Therapeutic response was evaluated by serum thyroglobulin (Tg) levels anatomical imaging changes. Results: analyses were performed 30 72 BMs....
Single injection of a small quantity phenol into the cortex one kidney in rats results development persistent hypertension (HTN) which is thought to be mediated by activation renal afferent and efferent sympathetic pathways sodium retention. Nitric oxide (NO) plays major role regulation vascular resistance, tubular Na(+) reabsorption, pressure natriuresis, thereby systemic arterial pressure. The present study was performed test hypothesis that chronic injury-induced HTN may associated with...
Abstract Background This study aimed to evaluate the performance of myocardial blood flow (MBF) and reserve (MFR) for diagnosing coronary artery disease (CAD) using dynamic single‐photon emission computed tomography/computed tomography (SPECT/CT) with a dual‐head rapidly rotating gantry (RRG) compare this method conventional perfusion imaging (MPI), which can be obtained in one‐stop manner. Methods A total 93 patients suspected or confirmed CAD who underwent RRG SPECT/CT were retrospectively...
We present a case of 13 years old boy who was hospitalized with 10 months history progressive pain and weakness in his lower extremities. The laboratory tests revealed slightly decreased phosphate 25-hydroxyvitamin D3, high alkaline phosphatase, normal calcium parathyroid hormone (PTH). Magnetic resonance imaging (MRI) showed multiple patchy lesions indicating bone destruction the metaphyses epiphyses left knee. Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography...
If there are grey variables in the constraint conditions uncertain programming, programming is called chance constrained programming. In this paper we provide concept of When whitenization weight functions known and distribution constructed, studied certainty equivalence solution different situations, given . Further, c onvexity feasible set study Then an optimization algorithm based on genetic suggested to solve model. Comparing with traditional power transmission system planning, more...
Significant reduction of renal mass triggers a chain events that result in glomerular hypertension/hyperfiltration, proteinuria, progressive glomerulosclerosis, tubulointerstitial injury, and end-stage disease. These are mediated by constellation hemodynamic, oxidative, inflammatory reactions, which are, part, caused local activation AT1 receptor (AT1r) angiotensin II (Ang II). In the present study, we explored effects (5/6 nephrectomy) with without AT1r blockade (losartan, 30 mg/kg/d for 8...