Previous investigators have observed a doubling of the mortality rate among patients with intermittent claudication, and we reported fourfold increase in overall subjects large-vessel peripheral arterial disease, as diagnosed by noninvasive testing. In this study, investigated association disease rates from all cardiovascular diseases coronary heart disease.

Because patients with peripheral arterial disease (PAD) may be asymptomatic or present atypical symptoms findings, the true population prevalence of PAD is essentially unknown. We used four highly reliable, sophisticated noninvasive tests (segmental blood pressure, flow velocity by Doppler ultrasound, postocclusive reactive hyperemia, and pulse reappearance half-time) to assess large-vessel small-vessel in an older (average age 66 years) defined 613 men women. A total 11.7% had on testing,...

In a companion article we have reported the prevalence, in an older, defined population, of traditional assessments (intermittent claudication and abnormal pulse examination) peripheral arterial disease (PAD) as compared with results highly accurate noninvasive testing. this report sensitivity, specificity, positive negative predictive values for pulses diagnosis large-vessel small-vessel PAD determined by Claudication were completely unrelated to isolated PAD. contrast, both significantly...

Background— Previous studies have indicated higher rates of peripheral arterial disease (PAD) in blacks than non-Hispanic whites (NHWs), with limited information available for Hispanics and Asians. The reason the PAD excess is unclear. Methods Results— Ethnic-specific prevalence were determined a randomly selected defined population that included 4 ethnic groups; NHWs, blacks, Hispanics, A total 2343 participants aged 29 to 91 years evaluated. There 104 cases (4.4%). In weighted logistic...

The WHO/Rose questionnaire has served as the epidemiologic and clinical standard in assessment of leg pain patients with peripheral arterial disease (PAD) for over three decades. However, structure this does not allow leg-specific (i.e. right versus left) symptoms. We studied 508 aged 39–95 years (mean 68 years), initially referred PAD non-invasive testing. A revised questionnaire, San Diego Claudication Questionnaire, was administered which allowed determination symptoms evaluated thigh...

Data on the natural history of peripheral arterial disease (PAD) are scarce and focused primarily clinical symptoms. Using noninvasive tests, we assessed role traditional novel risk factors PAD progression. We hypothesized that for large-vessel (LV-PAD) progression might differ from small-vessel (SV-PAD).Between 1990 1994, patients seen during prior 10 years in our vascular laboratories were invited a new examination. The first assessment provided baseline data, with follow-up data obtained...

A noninvasive technique for studying blood flow dynamics in human skin capillaries is described. light microscope combined with a closed-circuit TV system was used to monitor and record capillary velocity on video tape. Arterial pulsations were recorded plethysmographically converted into signals by modulating the position of square, white area televised scene. Twelve healthy subjects studied. The mean (+/- SD) resting 0.65 +/- 0.3 mm/s at an average temperature 30.4 2.3 degrees C....

Journal Article Screening for Peripheral Arterial Disease: The Sensitivity, Specificity, and Predictive Value of Noninvasive Tests in a Defined Population Get access Heather Spencer Feigelson, Feigelson 1Department Epidemiology, School Public Health, University CaliforniaLos Angeles, Los CA2Department Family Preventive Medicine, Division CaliforniaSan Diego, La Jolla, CA Search other works by this author on: Oxford Academic PubMed Google Scholar Michael H. Criqui, Criqui 2Department...

Intermittent claudication has been reported in previous studies to approximately double the risk of subsequent mortality. However, a history is often present absence significant peripheral arterial disease (PAD) and absent presence PAD. For this reason we evaluated association between large-vessel small-vessel PAD, measured by highly reliable valid noninvasive tests, mortality 567 older subjects from defined population followed-up for an average 4 years. Large-vessel PAD was strongly...

Journal Article PERIPHERAL ARTERIAL DISEASE IN LARGE VESSELS IS EPIDEMIOLOGICALLY DISTINCT FROM SMALL VESSEL DISEASE: AN ANALYSIS OF RISK FACTORS Get access MICHAEL H. CRIQUI, CRIQUI 1Department of Community and Family Medicine, University CaliforniaSan Diego, School La Jolla, CA2Department CA Reprint requests to Dr. Michael Criqui, Division Epidemiology, Department M-007, California, San 92093 Search for other works by this author on: Oxford Academic PubMed Google Scholar DEIRDRE BROWNER,...

Quantitative Doppler ultrasonographic flow velocity determinations are reported from 39 normal control subjects and 80 patients with angiographically documented peripheral arterial disease, in whom femoral, posterior tibial dorsalis pedis arteries were studied. The mean values of the most useful parameters were: femoral artery: peak forward (PFV) cm/sec: 40.7 +/- 10.9, deceleration (Dec.) cm/sec2:250.9 60.0, peak/mean (P/MV): 4.8 1.6; PFV: 16.0 10.0, Dec.: 129.8 75.7, P/MV: 2.5; 168 5.7,...

A new method is described for measuring blood flow in the femoral artery man, based on local thermodilution. The makes it possible to take 3 or 4 measurements per minute at rest and during muscular exercise of investigated limb. average eight subjects was 635.9±223.1 ml./min., 6.0±2.3 ml./100 ml. limb volume/min. Changes graded increased work loads were also measured 5-minute periods (150, 200, 250 Kg./min.). rate rise faster start a given period than latter half same period. After end load,...

There is little information on the progression of peripheral arterial disease (PAD) over time. A series 508 patients with a prior examination for PAD were contacted and brought in follow-up to evaluate natural history PAD. total 85 excluded because they had interventions both limbs their return visit. Progression was assessed remaining 423 755 limbs, quantitatively qualitatively using six categories severity. modest overall categorical disease: 228 (30.2%) displayed progression, while 172...

Background— Although exertional leg pain is a hallmark of peripheral arterial disease (PAD) and can occur in persons without PAD, symptom variation has received inadequate attention. Methods Results— Three cohort studies were combined for cross-sectional analysis. The San Diego Claudication Questionnaire assessed pain. PAD was defined as ankle brachial index (ABI) ≤0.90 or history lower-extremity revascularization. Of 3658 subjects, 3629 analyzed after exclusions. these, 24.1% had 1 both...