A5019081220- Adsorption, diffusion, and thermodynamic properties of materials
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Material Properties and Applications
- Food composition and properties
- Circadian rhythm and melatonin
- MicroRNA in disease regulation
- Thermal and Kinetic Analysis
- Pancreatic and Hepatic Oncology Research
- Plant Physiology and Cultivation Studies
- Advanced Theoretical and Applied Studies in Material Sciences and Geometry
- Geotechnical and Geomechanical Engineering
- Polymer Science and Applications
- Horticultural and Viticultural Research
- Advanced NMR Techniques and Applications
- Advanced Polymer Synthesis and Characterization
- Energetic Materials and Combustion
- Metabolism and Genetic Disorders
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Aerogels and thermal insulation
- Soil and Unsaturated Flow
- Epoxy Resin Curing Processes
- Epigenetics and DNA Methylation
- Spacecraft and Cryogenic Technologies
University of California, Riverside
2015-2023
Institute of Physics and Technology
1989
D. Mendeleyev University of Chemical Technology of Russia
1987
Institute of Chemical Technology
1987
Institute of Macromolecular Compounds
1984
Polymer Research Institute
1982
A. N. Nesmeyanov Institute of Organoelement Compounds
1978
Czech Academy of Sciences, Institute of Macromolecular Chemistry
1977
The nuclear receptor hepatocyte factor 4α (HNF4α) is tumor suppressive in the liver but amplified colon cancer, suggesting that it also might be oncogenic. To investigate whether this discrepancy due to different HNF4α isoforms derived from its two promoters (P1 and P2), we generated Tet-On-inducible human cancer (HCT116) cell lines express either P1-driven (HNF4α2) or P2-driven (HNF4α8) isoform analyzed them for growth global changes gene expression (transcriptome sequencing [RNA-seq]...
Hepatocyte Nuclear Factor 4α (HNF4α), a master regulator of hepatocyte differentiation, is regulated by two promoters (P1 and P2) which drive the expression different isoforms. P1-HNF4α major isoform in adult liver while P2-HNF4α thought to be expressed only fetal cancer. Here, we show that indeed normal at Zeitgeber time (ZT)9 ZT21. Using exon swap mice express this orchestrates distinct transcriptome metabolome via unique chromatin protein-protein interactions, including with clock...
Abstract Hepatocyte Nuclear Factor 4α (HNF4α), a master regulator of hepatocyte differentiation, is regulated by two promoters (P1 and P2). P1-HNF4α the major isoform in adult liver while P2-HNF4α thought to be expressed only fetal cancer. Here, we show that P2- HNF4α at ZT9 ZT21 normal orchestrates distinct transcriptome metabolome via unique chromatin protein-protein interactions. We demonstrate drives gluconeogenesis, ketogenesis required for elevated levels ketone bodies females. Exon...
The influence of the bioregulator Reglalg with microelements B, Zn, Mn, Mo on leave pigment system local species and foreign selection pear plum trees, introduced in Moldova, was studied. Investigations have shown drought protection a high stimulatory effect such treatment content chlorophylls carotenoids leaves studied fruit plants.
С развитием альтернативных источников энергии актуальной является задача разработки и совершенствования водорода для топливных элементов. В такой задаче перспективной представляется реализация реакции нанодисперсного алюминия с водой, протекающей большим выделением за короткое время. Взаимодействие высокой дисперсности водой необходимо контролировать, чтобы не допустить резкого нарастания давления температуры. Для этого предлагается использовать дозированную подачу порошка в воду...
Во многих практических приложениях необходимо порционно вводить мелкодисперсные порошки импульсными методами распыления в водную среду, например, водородной энергетике для получения электричества. При этом контролируется полнота реагирования мелкодисперсного порошка с водной средой. Целью работы является исследование процессов импульсного диспергирования компактированных порошков среде равномерного распределения гидрозоле. Порошки, предварительно компактированные на прессовом оборудовании,...
Nuclear receptor genes often contain alternative promoters but the physiological relevance of different or proteins they generate is largely unknown. Hepatocyte Factor 4α (HNF4α), master regulator hepatocyte differentiation and most abundant nuclear in liver, regulated by two (P1 P2). P1-HNF4α, a tumor suppressor, major isoform adult liver while P2-HNF4α expressed fetal cancer: role for normal has not been identified. Here we show first time that at ZT9 ZT21 use P2-HNF4α-expressing exon swap...