A5039246775- Plant-based Medicinal Research
- Reconstructive Facial Surgery Techniques
- 3D Printing in Biomedical Research
- Bone Tissue Engineering Materials
- Axial and Atropisomeric Chirality Synthesis
- Ear and Head Tumors
- Nasal Surgery and Airway Studies
- Electrospun Nanofibers in Biomedical Applications
- Ear Surgery and Otitis Media
- Berberine and alkaloids research
- Bioactive Natural Diterpenoids Research
- Alkaloids: synthesis and pharmacology
- Additive Manufacturing and 3D Printing Technologies
- Oral and Maxillofacial Pathology
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Peking Union Medical College Hospital
2024
Southwest Jiaotong University
2018-2019
Abstract Despite recent advances in extrusion bioprinting of cell‐laden hydrogels, using naturally derived bioinks to biofabricate complex elastic tissues with both satisfying biological functionalities and superior mechanical properties is hitherto an unmet challenge. Here, we address this challenge precisely designed tough hydrogel featuring a double‐network structure. The hydrogels consisted energy‐dissipative dynamically crosslinked glycosaminoglycan hyaluronic acid...
A new C19 diterpenoid alkaloid, brevicanine (1) and six known ones (2-7) were isolated from Aconitum brevicalcaratum (Finet et Gagnep.) Diels. Their structures elucidated on the basis of extensive spectroscopic analyses. The cytotoxicity those compounds was investigated against HCT116 human cancer cell line, which showed none them possessing considerable anti-proliferative activities. To evaluate autophagy effect 1-7, Western blot used to detect expression autophagic marker by stimulating...
3D bioprinting of elastic cartilage tissues that are mechanically and structurally comparable to their native counterparts, while exhibiting favorable cellular behavior, is an unmet challenge. A practical solution for this problem the multi-material thermoplastic polymers cell-laden hydrogels using multiple nozzles. However, processing requires high temperatures, which can damage hydrogel-encapsulated cells. In study, authors developed waterborne polyurethane (WPU)-polycaprolactone (PCL)...
Nonsyndromic microtia is a kind of congenital ear malformation with unclear pathogenic genes. Cadherin-11 (CDH11, OB-cadherin) member the cadherin family, which has been demonstrated to play important roles in controlling morphogenesis and cell biological characteristics during multiple developmental processes. In present study, we found low expression CDH11 cartilage compared normal one for first time. For more comprehensive in-depth understanding development, performed both gain-...