Chien Chen

ORCID: 0009-0003-6683-9781
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About
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Research Areas
  • Ultrasound Imaging and Elastography
  • Photoacoustic and Ultrasonic Imaging
  • Chronic Kidney Disease and Diabetes
  • Optical Coherence Tomography Applications
  • Acute Kidney Injury Research
  • Ultrasound in Clinical Applications
  • Lower Extremity Biomechanics and Pathologies
  • Genomic variations and chromosomal abnormalities
  • Cardiovascular Health and Disease Prevention
  • Elasticity and Material Modeling
  • Fetal and Pediatric Neurological Disorders
  • Microtubule and mitosis dynamics
  • Renal and Vascular Pathologies

National Cheng Kung University
2023-2025

Taipei Medical University Hospital
2023

COMSATS University Islamabad
2023

National Yang Ming Chiao Tung University
2022-2023

Universidade do Vale do Itajaí
2023

Taipei Veterans General Hospital
2022

Shear wave elastography (SWE) is a quantitative imaging method that could be used for clinical assessment of musculoskeletal stiffness, particularly in disease diagnosis and rehabilitation evaluation. However, the elastic anisotropy skeletal muscle leads to uncertainties shear velocity (SWV) measurements SWE because SWV varies with fiber orientation. Therefore, many studies have conducted 360° rotational determine muscle; however, extended data acquisition time this approach limits its...

10.1109/tmi.2025.3541321 article EN IEEE Transactions on Medical Imaging 2025-01-01

Abstract Although the relationships of cerebrovascular hemodynamic dysfunction with neurodegenerative diseases remain unclear, many studies have indicated that poor cerebral perfusion accelerates progression diseases, such as Alzheimer's disease (AD). Small animal models are widely used in AD research. However, providing an imaging modality a high spatiotemporal resolution and sufficiently large field view to assess hemodynamics vivo remains challenge. The present study proposes novel...

10.1002/advs.202302345 article EN cc-by Advanced Science 2023-11-14

Pathogenic variants in DCX on the X chromosome lead to lissencephaly and subcortical band heterotopia (SBH), brain malformations caused by neuronal migration defects. Its product doublecortin (DCX) binds microtubules modulate microtubule polymerization. How pathogenic affect these activities remains not fully investigated.DCX were identified using whole exome Sanger sequencing from six families with lissencephaly/SBH. We examined how functions binding, regrowth, colocalization assays.We...

10.1111/epi.17198 article EN Epilepsia 2022-02-25

The shoulder is the most mobile joint in human body, thus requiring intricate coordination of adjacent muscles. Patients suffered from rotator cuff muscle injuries have several typical symptoms including pain and difficulty raising arm, reducing work efficiency compromising quality life. Ultrasound has been used widely for soft tissue imaging as well ultrasound elastography was introduced examination dilemma treating degenerative tears. However, performed under a static condition. Providing...

10.1109/tuffc.2023.3348472 article EN IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control 2024-01-01

Abstract Background The skin is the largest organ of human body and serves distinct functions in protecting body. viscoelastic properties play a key role supporting skin‐healing process, also it may be changed due to some diseases. Propose In this study, high‐frequency ultrasound (HFUS) elastography based on Lamb wave model was used noninvasively assess anisotropy skin. Method Elastic waves were generated through an external vibrator, propagation velocity measured 40 MHz ultrafast HFUS...

10.1002/mp.17372 article EN Medical Physics 2024-09-03

Abstract Introduction Contrast-induced nephropathy (CIN) is increasingly prevalent as the increased age and comorbidities. Though most CIN can be reversible, some may progress to acute kidney disease (AKD) subsequent chronic (CKD)1-3. Sodium–glucose cotransporter-2 (2SGLT) inhibitor has been known bring better renal outcomes 4-7. However, whether it affect contrast-induced injury not well. we Purpose We aimed investigate post-contrast exposure in patients with diabetes SGLT2 inhibitor....

10.1093/eurheartj/ehad655.2816 article EN European Heart Journal 2023-11-01
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