A5011806109- Autoimmune and Inflammatory Disorders Research
- Immunodeficiency and Autoimmune Disorders
- Neonatal and Maternal Infections
- Streptococcal Infections and Treatments
- Sepsis Diagnosis and Treatment
- Kawasaki Disease and Coronary Complications
- Inflammasome and immune disorders
- Adolescent and Pediatric Healthcare
- Hematological disorders and diagnostics
- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Cardiac Structural Anomalies and Repair
- Immune Cell Function and Interaction
- Orthopedic Infections and Treatments
- Bacterial Infections and Vaccines
- Lymphadenopathy Diagnosis and Analysis
- Pneumonia and Respiratory Infections
- Genetics and Neurodevelopmental Disorders
- Power Line Communications and Noise
- Islanding Detection in Power Systems
- Science and Science Education
- HIV/AIDS Research and Interventions
- Power Quality and Harmonics
- Bacterial Identification and Susceptibility Testing
- Hepatitis C virus research
Hospital Universitario Virgen del Rocío
2019-2023
Instituto de Biomedicina de Sevilla
2023
Hospital Universitari i Politècnic La Fe
2019
Centro de Reprodução Humana Prof. Franco Junior
2018
Universidade de Ribeirão Preto
2018
Leitat Technological Center
2014
Universidade Estadual de Campinas (UNICAMP)
2013
Hospital Universitario de Getafe
2010
Hospital de Sagunto
2010
Gain-of-function mutations in STING1 cause the monogenic interferonopathy, SAVI, which presents with early-onset systemic inflammation, cold-induced vasculopathy and/or interstitial lung disease. We identified 5 patients (3 kindreds) predominantly peripheral vascular disease who harbor 3 novel variants, p.H72N, p.F153V, and p.G158A. The latter two were predicted by a previous cryo-EM structure model to STING autoactivation. p.H72N variant exon 3, however, is first SAVI-causing transmembrane...
Fosamprenavir (FPV) efficacy in human immunodeficiency virus (HIV)-infected pediatric patients is still being evaluated ongoing clinical trials. The long-term and safety of FPV boosted with ritonavir (FPV/r) was 20 antiretroviral-naive antiretroviral-experienced HIV-vertically infected patients. Analyses CD4(+) T-cells, HIV-ribonucleic acid (RNA), status were performed during a median 180 weeks. Initially, HIV-RNA 4.6 log(10) naive 4.4 pretreated Median T-cell 17% 31%, respectively. After...
Raynaud’s phenomenon (RP) appears to be underestimated in the pediatric population and its prevalence is unknown. However, RP earliest most common clinical manifestation of diffuse connective tissue diseases. Nailfold capillaroscopy an easily performed, non-traumatic low cost technique, with a confirmed role discrimination between primary secondary RP, playing important assessment autoimmune rheumatic diseases.
Tumour Necrosis Factor (TNF) Receptor-Associated Periodic Syndrome (TRAPS) is an autoinflammatory disease with autosomal dominant inheritance pattern. Structural mutations in the TNFRSF1A gen tend to have a penetrance higher than 90%, except for p.P46L and p.R92Q variants. The intensity of clinical manifestations patients these variants has been shown decrease or even disappear long term follow-up. It found high prevalence R92Q mutation inflammatory diseases known relevant TNF-alfa involvement.
<h3>Background</h3> The nervous system affects children and adults with systemic lupus erythematosus (SLE) is associated a worse prognosis elevated mortality. In juvenil onset SLE (jSLE) the prevalence of neuropsychiatric manifestations even more frequently observed when compared to adult SLE. <h3>Objectives</h3> To analyze in jSLE. <h3>Methods</h3> We conducted retrospective study including all patients jSLE followed by pediatric rheumatology clinic Unicamp disease before 16 years age. were...
Introdução: Pacientes neurocirúrgicos oncológicos têm alto risco de complicações no perioperatório, além altas taxas morbimortalidade.
<h3>Background:</h3> Pediatric patients with rheumatic diseases (RD) are at increased risk of infections. Vaccines have been proved to be very effective prevent them. Nevertheless the long-term immunity after vaccination remains quite unknown in this group. <h3>Objectives:</h3> To comapre long term seroprotecction pediatric who recieved measles, rubella, mumps, tetanus, diphteria, hepatitis B, hib and meningoccocus C acording routine immunization schedule Spain, healthy children....
<h3>Background</h3> The choice of the initial biological therapy for patients with suspected autoinflammatory diseases and not conclusive genetic test remains challenging. <h3>Objectives</h3> To assess clinical response to in pediatric disease no diagnosis. <h3>Methods</h3> We retrospectively reviewed charts followed our clinic who started empirical after being diagnosed disease(sAID) due intensity their symptoms colchicin or FAMEs. Next generation sequencing using an immune...