A5101506195- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Innovations in Medical Education
- Health Sciences Research and Education
- Alzheimer's disease research and treatments
- Advances in Oncology and Radiotherapy
The University of Texas Southwestern Medical Center
2023-2025
Rice University
2023
Baylor College of Medicine
2023
Great effort has been devoted to the synthesis of novel multi-target directed tacrine derivatives in search new treatments for Alzheimer's disease (AD). Herein we describe proof concept MBA121, a compound designed as tacrine-ferulic acid hybrid, and its potential use therapy AD. MBA121 shows good β-amyloid (Aβ) anti-aggregation properties, selective inhibition human butyrylcholinesterase, neuroprotection against toxic insults, such Aβ1-40, Aβ1-42, H2O2, promising ADMET properties that...