A5101883679- Click Chemistry and Applications
- Multicomponent Synthesis of Heterocycles
- Synthesis and biological activity
- Chemical Synthesis and Analysis
- PI3K/AKT/mTOR signaling in cancer
- Peptidase Inhibition and Analysis
- Cancer Genomics and Diagnostics
- Ubiquitin and proteasome pathways
- Synthesis and Biological Evaluation
- Lung Cancer Treatments and Mutations
University of Dundee
2024-2025
There is a continuous and pressing need to establish new brain-penetrant bioactive compounds with anti-cancer properties. To this end, series of 4'-((4-substituted-4,5-dihydro-1H-1,2,3-triazol-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile (OTBN-1,2,3-triazole) derivatives were synthesized by click chemistry. The designed from diverse alkynes N
Twenty-three new derivatives of ( R / S )-TDHPM-5-carboxanilide have been synthesized with up to 99% yield. All racemates were separated using chiral HPLC (Prep LC) which provided 99.99% purity. AC was determined circular dichroism spectra.
The vast majority of clinical small molecule multi-kinase inhibitors (mKI) report abject failures in targeting cancers with high stem cell contents like high-grade glioma and colorectal cancers. FDA-approved mKIs to date ablate receptor tyrosine kinase signaling but do not target the paradoxical WNT which is a key survival driver for self-renewing cancer cells. pathway enhances plasticity triggers relapse highly heterogenous tumours. Using de novo synthesis structure-activity-relationship...
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