A5030021311- DNA Repair Mechanisms
- Genomics and Chromatin Dynamics
- PARP inhibition in cancer therapy
- Cancer Genomics and Diagnostics
- Traumatic Brain Injury Research
- CRISPR and Genetic Engineering
- Neurobiology of Language and Bilingualism
- Telemedicine and Telehealth Implementation
- Educational and Psychological Assessments
- Glioma Diagnosis and Treatment
- Stroke Rehabilitation and Recovery
Rhode Island College
2023-2024
Providence College
2023-2024
Brown University
2024
Mercer University
2021
East Carolina University
2018
DNA polymerase θ (Pol or POLQ) is primarily involved in repairing double-stranded breaks through an alternative pathway known as microhomology-mediated end joining (MMEJ) theta-mediated (TMEJ). Unlike other repair polymerases, Pol thought to be highly error-prone yet critical for cell survival. We have identified several POLQ gene variants from human melanoma tumors that experience altered activity, including a propensity incorrect nucleotide selection and reduced polymerization rates...
Mutations in isocitrate dehydrogenase isoform 1 (IDH1) are primarily found secondary glioblastoma (GBM) and low-grade glioma but rare primary GBM. The standard treatment for GBM includes radiation combined with temozolomide, an alkylating agent. Fortunately, IDH1 mutant gliomas sensitive to this treatment, resulting a more favorable prognosis. However, it's estimated that up 75 % of will progress WHO grade IV over time develop resistance agents. Therefore, understanding the mechanism(s) by...
Abstract Background Due to the recent COVID‐19 pandemic, many clinicians have transitioned telehealth‐based cognitive assessments as a practical alternative in‐person evaluations. Meta‐analysis has shown that verbally‐mediated measures of cognition are most easily adapted telehealth administration, while include visual or motor components more variably impacted. The Oral Trail Making Test (O‐TMT) is one verbal measure executive function removes and demands. However, there dearth research...
Abstract DNA Polymerase θ (Pol or POLQ) is primarily involved in repairing double-stranded breaks through the alternative pathway known as microhomology-mediated end joining (MMEJ) theta-mediated (TMEJ). Unlike other repair polymerases, Pol thought to be highly error prone, yet critical for cell survival. We have identified several mutations POLQ gene from human melanoma tumors. Through biochemical analysis, we demonstrated that all three cancer-associated variants experienced altered...