A5110863484- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Infectious Aortic and Vascular Conditions
- Cardiac Structural Anomalies and Repair
- Vascular Procedures and Complications
- Congenital Heart Disease Studies
- Connective tissue disorders research
- Trauma Management and Diagnosis
- Hip and Femur Fractures
- Intracranial Aneurysms: Treatment and Complications
- Abdominal vascular conditions and treatments
- Trauma and Emergency Care Studies
- Cardiac and Coronary Surgery Techniques
- Cardiac Arrest and Resuscitation
- Central Venous Catheters and Hemodialysis
- Mechanical Circulatory Support Devices
- Venous Thromboembolism Diagnosis and Management
- Coronary Artery Anomalies
- Cerebrovascular and Carotid Artery Diseases
- Infective Endocarditis Diagnosis and Management
- Renal and Vascular Pathologies
- Peripheral Artery Disease Management
- Dialysis and Renal Disease Management
The University of Texas Health Science Center at Houston
2015-2024
Copenhagen University Hospital
2024
Rigshospitalet
2024
University of Houston
1999-2022
Memorial Hermann
2011-2020
Memorial Hermann–Texas Medical Center
2013-2019
Texas Medical Center
2013-2019
The University of Texas at Austin
2006-2017
Baylor College of Medicine
1994-2016
Stanford University
2015-2016
The vascular smooth muscle cell (SMC)-specific isoform of alpha-actin (ACTA2) is a major component the contractile apparatus in SMCs located throughout arterial system. Heterozygous ACTA2 mutations cause familial thoracic aortic aneurysms and dissections (TAAD), but only half mutation carriers have disease. Linkage analysis association studies individuals 20 families with indicate that can diversity diseases, including premature onset coronary artery disease (CAD) ischemic strokes (including...
Background— A genetic predisposition for progressive enlargement of thoracic aortic aneurysms leading to type dissection (TAAD) is inherited in an autosomal-dominant manner up 19% patients, and a number chromosomal loci have been identified the condition. Having mapped TAAD locus 3p24–25, we sequenced gene transforming growth factor-β receptor II ( TGFBR2 ) determine whether mutations this resulted familial TAAD. Methods Results— We all 8 coding exons by using genomic DNA from 80 unrelated...
Mutations in several genes have been identified that are responsible for 25% of families with familial thoracic aortic aneurysms and dissections. However, the causative gene remains unknown 75% families.To identify mutation autosomal dominant inheritance dissections.Exome sequencing was used to a large family A heterozygous rare variant, c.839G>T (p.Ser280Arg), LOX, encoding lysyl oxidase, segregated disease family. Sanger exome investigate mutations LOX an additional 410 probands from...
To report the long-term results of our experience using cerebrospinal fluid drainage and distal aortic perfusion in descending thoracic thoracoabdominal repair.Repair aneurysm by traditional clamp-and-go technique a massive ischemic insult to several major organ systems. Ten years ago, we began use (adjunct) reduce end-organ ischemia.Between January 1991 February 2003, performed 1004 or repairs. Adjunct was used 741 (74%) 1004. Multivariable data were analyzed Cox regression. Number needed...
Non-syndromic thoracic aortic aneurysms and dissections (TAADs) are inherited in an autosomal dominant manner ∼20% of cases. Familial TAAD is genetically heterogeneous four loci have been mapped for this disease to date, including a locus at 16p associated with patent ductus arteriosus (PDA). The defective gene the has recently identified as smooth muscle cell (SMC)-specific myosin heavy chain (MYH11). On sequencing MYH11 93 families alone three TAAD/PDA, we novel mutations two but none...
Currently, the optimal treatment of acute type B aortic dissection remains controversial. The purpose this study was to report early clinical outcomes medical management for dissection.Between January 2001 and March 2005, 129 consecutive patients with confirmed diagnosis were studied. Mean age 61 years (range, 29 94), 33.3% (43/129) female. Acute protocol instituted intent manage all medically. Indications surgical intervention included rupture, expansion, malperfusion, intractable pain. All...