A5087258137- Acute Myeloid Leukemia Research
- Cancer Genomics and Diagnostics
- Erythrocyte Function and Pathophysiology
- Phagocytosis and Immune Regulation
- Histone Deacetylase Inhibitors Research
- Evolution and Paleontology Studies
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- interferon and immune responses
- Immune Cell Function and Interaction
- Ubiquitin and proteasome pathways
Washington University in St. Louis
2022-2025
Stathmin 1 is a cytoplasmic phosphoprotein that regulates microtubule dynamics via promotion of catastrophe and sequestration free tubulin heterodimers. highly expressed in hematopoietic stem cells (HSCs), overexpressed leukemic cells, however its role HSCs not known. Herein, we found loss associated with altered architecture HSCs, markedly impaired HSC function. Transcriptomic studies suggested alterations oxidative phosphorylation Stmn1 -/- further mechanistic revealed defective...
The role of polyunsaturated fatty acid (PUFA) biosynthesis in acute myeloid leukemia (AML) remains largely undefined. A comparative expression analysis 35 genes encoding enzymes showed that desaturase 1 (FADS1) was highly expressed across multiple AML subtypes relative to healthy controls and elevated FADS1 correlates with worse overall patient survival. Functionally, shRNA-mediated inhibition reduced cell growth vitro significantly delayed onset an mouse model. lines depleted arrested the...