A5021362749- Diabetes and associated disorders
- Immune Cell Function and Interaction
- Pancreatic function and diabetes
- Helicobacter pylori-related gastroenterology studies
- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Immunodeficiency and Autoimmune Disorders
- Mycobacterium research and diagnosis
- Diet, Metabolism, and Disease
- Nuclear Physics and Applications
- Influenza Virus Research Studies
- Vaccine Coverage and Hesitancy
- Viral gastroenteritis research and epidemiology
- Radiation Detection and Scintillator Technologies
- Advanced Glycation End Products research
- Particle accelerators and beam dynamics
- Atherosclerosis and Cardiovascular Diseases
- Protein Tyrosine Phosphatases
- Pharmaceutical studies and practices
- Digestive system and related health
- Health Systems, Economic Evaluations, Quality of Life
- Biosimilars and Bioanalytical Methods
- T-cell and B-cell Immunology
- Celiac Disease Research and Management
- Infant Nutrition and Health
National Research Council
2025
National Institute of Optics
2024
Policlinico Tor Vergata
2012-2016
University of Rome Tor Vergata
2005-2016
Mycobacterium avium subspecies paratuberculosis (MAP) has been previously associated to T1D as a putative environmental agent triggering or accelerating the disease in Sardinian and Italian populations. Our aim was investigate role of MAP development by evaluating levels antibodies directed against epitopes their human homologs corresponding ZnT8 proinsulin (PI) 54 at-risk children from mainland Italy 42 healthy controls (HCs). A higher prevalence detected for MAP/ZnT8 pairs (62,96% vs....
Abstract The missense PTPN22 C1858T polymorphism recently emerged as an important population‐independent risk factor for type 1 diabetes (T1D) and other autoimmune diseases. gene encodes the lymphoid tyrosine phosphatase (LYP), a negative regulator of signal transduction through T‐cell receptor. Although frequency is variable among different ethnic groups, association between *T1858 T1D has been replicated in several populations. Here, we contribute first replication populations from...
Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of Johne’s disease in ruminants. Recent studies have linked MAP to type 1 diabetes (T1D) Sardinian population. The aim this study was investigate prevalence infection a T1D cohort from continental Italy compared with healthy control subjects. 247 subjects and 110 controls were tested for presence MAP. DNA detected using IS900-specific polymerase chain reaction (PCR). antibodies towards antigen, heparin binding...
Mycobacterium avium subspecies paratuberculosis (MAP) asymptomatic infection is speculated to play a role in type 1 diabetes (T1D) among Sardinian subjects. Data obtained analyzing pediatric population from mainland Italy lends support the hypothesis, which envisions MAP as an environmental factor at T1D pathogenesis. Aiming investigate likelihood of cross-recognition between linear determinants shared by self (proinsulin) and non-self proteins, 59 children with new onset 60 healthy controls...
The importance of dendritic cells (DC) in the activation T and maintenance self-tolerance is well known. We investigated whether alterations phenotype function DC may contribute to pathogenesis Type 1 diabetes (T1DM). Mature (mDC) from 18 children with T1DM 10 age-matched healthy were tested. mDC, derived peripheral blood monocytes cultured for 6 days presence interleukin (IL)-4 granulocyte-macrophage colony stimulating factor (GM-CSF) stimulated lipopolysaccharide (LPS) last 24 h,...
In type 1 diabetes mellitus (T1D) p53 pathways are up-regulated and there is an increased susceptibility to apoptosis. The hypothesis that codon 72 polymorphism could be associated with T1D. A total of 286 children T1D a control sample 730 subjects were studied. was analysed by polymerase chain reaction. large increase *Arg/*Arg observed in patients age at onset < 6 years. strong linear correlation between genotype females. involvement the apoptosis suggests during autoimmune process leading...
Aims/Hypothesis Although numerous environmental agents have been investigated over the years as possible triggers of type 1 diabetes (T1D), its causes remain unclear. We already demonstrated an increased prevalence antibodies against peptides derived from Mycobacterium avuim subsp. paratuberculosis (MAP) homologous to human zinc transporter 8 protein (ZnT8) and proinsulin in Italian subjects at risk for or affected by T1D. In this study, we compared titers previously detected with...
We investigated whether the PTPN22 C1858T polymorphism is associated with autoimmune conditions present in family of a child affected by type 1 diabetes (T1D) carrying TT genotype (index patient) and potential immunological effect variant. found that nine members carried CT five suffered from autoimmunity. Interestingly, anti-ZnT8 antibodies were detected T1D patients three healthy relatives. In patient, we showed diminished T-cell proliferation reduced interleukin-2 (IL-2) interferon-gamma...