A5093579568- Olfactory and Sensory Function Studies
- Extracellular vesicles in disease
- RNA regulation and disease
- MicroRNA in disease regulation
- Pregnancy and preeclampsia studies
- Neuroinflammation and Neurodegeneration Mechanisms
- COVID-19 Impact on Reproduction
UCLouvain
2023
Olfactory impairment is a recognized early indicator of neurodegenerative diseases (NDs), such as Alzheimer's disease (AD). Intracellular aggregates hyperphosphorylated tau protein, referred to neurofibrillary tangles (NFTs), are hallmark AD. NFTs found in the olfactory bulb (OB) and entorhinal cortex (EC), both crucial for processing information. We explored hypothesis that typical lesions could appear progress along regions reach connected areas critically affected AD (e.g. EC hippocampal...
Abstract INTRODUCTION Amyloid-β (Aβ) and tau are brain hallmarks of Alzheimer’s disease (AD) also present in blood as soluble biomarkers or encapsulated extracellular vesicles (EVs). Our goal was to assess how plasma AD pathology correlate with number content EVs. METHODS Single-molecule enzyme-linked assays were used quantify Aβ42/40 samples neurally-derived EVs (NDEVs) from a cohort APOE ε4– ε4+ cognitively normal individuals (CN) patients. RESULTS Soluble ratio is decreased patients...
Abstract Background Amyloid-β (Aβ) and tau are brain hallmarks of Alzheimer’s disease (AD), also present in blood as soluble biomarkers or encapsulated extracellular vesicles (EVs). Our goal was to assess how plasma AD pathology correlate with the number content EVs. Methods Single-molecule enzyme-linked assays were used quantify Aβ42/40 samples neurally-derived EVs (NDEVs) from a cohort APOE ε4– ( n = 168) ε4+ 68) cognitively normal individuals patients 55). The ratio CD56 (Neuronal...
Abstract Background Clinical data indicate that impairment of olfactory function is an early indicator neurodegenerative diseases, including Alzheimer’s disease (AD)( Attems et al., 2014) . Our hypothesis typical AD lesions could appear in neurons from the epithelium (OE). The can be easily collected human individuals (e.g., by nasal brushing), which provides important tool to investigate pathology patients. Here, we address question occurrence tauopathy OE transgenic mice and its...