A5080478398- Carcinogens and Genotoxicity Assessment
- Air Quality and Health Impacts
- Computational Drug Discovery Methods
- Cholinesterase and Neurodegenerative Diseases
- Anesthesia and Neurotoxicity Research
- Occupational exposure and asthma
- Synthesis and biological activity
- Contact Dermatitis and Allergies
- Nanoparticles: synthesis and applications
- Immunotoxicology and immune responses
- Chemical Safety and Risk Management
- Indoor Air Quality and Microbial Exposure
- DNA and Nucleic Acid Chemistry
- Heavy Metal Exposure and Toxicity
- DNA Repair Mechanisms
- Sulfur Compounds in Biology
- Free Radicals and Antioxidants
- Anesthesia and Sedative Agents
- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Cytomegalovirus and herpesvirus research
- Pesticide Exposure and Toxicity
- Animal testing and alternatives
- Hydrogen's biological and therapeutic effects
- Analytical chemistry methods development
Bülent Ecevit University
2024
Eskişehir City Hospital
1992-2024
Anadolu University
2023-2024
Ankara University
1994-2017
Gazi University
1988-2002
National Institute of Standards and Technology
1996-1997
The kinetics of excision damaged purine bases from oxidatively DNA by Escherichia coli Fpg protein were investigated. substrates, prepared treatment with H 2 O /Fe(III)-EDTA or γ-irradiation under N air, incubated protein, followed precipitation DNA. Precipitated and supernatant fractions analyzed gas chromatography/isotope-dilution mass spectrometry. Kinetic studies revealed efficient 8-hydroxyguanine (8-OH-Gua), 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua)...
Uracil DNA N-glycosylase is a repair enzyme that releases uracil from DNA. A major function of this presumably to protect the genome pre-mutagenic resulting deamination cytosine in Here, we report human also recognizes three derivatives are generated as products by hydroxyl radical attack or other oxidative processes. substrates were prepared gamma-irradiation aerated aqueous solution and incubated with N-glycosylase, heat-inactivated buffer. Ethanol-precipitated supernatant fractions then...
Abstract Thiosemicarbazone derivative was obtained by the addition of thiosemicarbazide to 5‐nitro‐thiophene‐2‐carbaldehyde. The addition–cyclization 2‐bromoacetophenone thiosemicarbazone gave new thiazole derivatives ( 2 a‐k ). Acetylcholinesterase (AChE), butyrylcholinesterase (BChE), antioxidant, and human carbonic anhydrase (hCA) I II isoform inhibitory activities were investigated. effects on (hCA I–II) isoenzymes examined in vitro using esterase method. IC 50 values for enzyme...
Heterocyclic compounds including pyrazole have a serious area in the field of medicinal chemistry and modern drug development studies. Pyrazole is five-membered ring system containing two adjacent nitrogen atoms. attracts great attention due to its wide biological activity scale potential new molecules. Traditional methods been used general synthesis for long time, but since these can be performed within certain limits, it necessary benefit from sustainable methodologies. In this review, use...
Abstract Cancer is the second leading cause of death today and remains a threat to human health. The advent multi‐drug resistance adverse effects make current first‐line anti‐cancer medicines inadequate, despite fact that numerous efforts have been made in field cancer therapy significant progress has diagnosis treatment cancer. Consequently, development novel anticancer drugs with high activity minimal toxicity imperative. benzimidazole ring attracted attention medicinal chemists due its...
Coal workers’ pneumoconiosis (CWP) is an occupational pulmonary disease that occurs by chronic inhalation of coal dust. CWP divided into two stages depending on the extent disease, as simple (SP) and progressive massive fibrosis (PMF). In present study, serum bronchoalveolar lavage (BAL) cytokine (interleukin-1β [IL-1β], IL-6, tumor necrosis factor-α [TNF-α], transforming growth factor-β [TGF-β]) antioxidant enzymes levels, their relation with severity, whether they can be considered...
1 To assess the quantitative relation between exposure to airborne cadmium and various markers of immune function, 37 male workers were examined compared with unexposed controls. 2 Blood concentrations signficantly , higher in exposed than unexposed, as was urine cadmium. 3 No differences serum immunoglobulin (IgG, IgM IgA) levels two popularions observed, There also no significant correlation blood both control groups, It has been found that while monocyte counts increased, lymphocyte,...
1 To estimate the quantitative relation between exposure to airborne n-hexane and various markers of immune function, 35 male workers were examined compared with unexposed controls. 2 Urinary 2,5-hexanedione concentrations signifi cantly higher in exposed group than unexposed. 3 A significant suppression was observed serum immunoglobulin (IgG, IgM IgA) levels two populations. Also, a correlation found urinary Ig level group. 4 No difference white blood cell counts groups.
Lead and cadmium are common environmental contaminants that alter the immune response. Natural killer cell (NK) cytotoxicity phenotypic parameters crucial responses, but little is known about effects of these metals on responses. In present paper, we investigated simultaneous lead NK activity CD4+, CD20+ percentages in workers compared data with control lead-exposed groups. We conclude exposure to not associated an impairment either function or CD4+ percentage. On other hand, percentage was...
The immunological status of individuals occupationally exposed to low levels halothane and nitrous oxide has been examined compared with that non-exposed controls. No differences in the serum concentrations IgG, IgM, IgA, peripheral blood lymphocytes lymphocyte subpopulations between groups were observed.
Human serum paraoxonase is a polymorphic enzyme that capable of catalyzing the hydrolysis paraoxon and other organophosphates, some carbamates certain aromatic carboxylic acid esters. This specified by two allelic genes at one autosomal locus (isozymes ‘A’ ‘B’). The purpose this study was to examine activity 105 Turkish subjects. Paraoxonase activities ranged from 39.6 278.2 nmol p-nitrophenol formed per ml min. phenotypes could be clearly identified salt paraoxonase:arylesterase ratio...
In this research, we report the synthesis and evaluation of novel thiosemicarbazones as anti-Alzheimer’s agents. The structural clarification newly synthesized compounds was carried out by 1H NMR, 13C MS analyses. According to in vitro cholinesterase inhibition assay, showed more inhibitory potential against AChE than BuChE. antioxidant activity measured via two different methods. ferrous ion-chelating assay compound 2b demonstrated 5.26% when compared BHT (2.57%). DPPH radical scavenging...
In this study, 7 new thiazole derivatives were synthesized. Cholinesterase inhibition and antioxidant properties examined to understand whether the synthesized compounds anti-Alzheimer drug candidates. The of these newly their enzyme values for acetylcholinesterase (AChE) butyrylcholinesterase (BuChE) evaluated. According data, substances inhibited AChE BuChE enzymes at deficient levels. Compound 2e showed highest effect with a value 20.32 ± 0.005% 50 µM concentration. Although high activity...