A5022863099- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Asymmetric Synthesis and Catalysis
- Synthesis and biological activity
- Cancer therapeutics and mechanisms
- Oxidative Organic Chemistry Reactions
- Computational Drug Discovery Methods
Scripps Research Institute
2023-2025
Scripps (United States)
2024
Scripps Institution of Oceanography
2024
The synthesis of quaternary carbons often requires numerous steps and complex conditions or harsh reagents that act on heavily engineered substrates. This is largely a consequence conventional polar-bond retrosynthetic disconnections in turn require multiple functional group interconversions, redox manipulations, protecting chemistry. Here, we report simple catalyst reductant combination converts two types feedstock chemicals, carboxylic acids olefins, into tetrasubstituted through...
A concise, scalable total synthesis of (–)-Bipinnatin J is disclosed. Commencing from inexpensive starting materials, this marine diterpenoid was fashioned through a highly convergent enabled by Ni-electrocatalytic decarboxylative cross–coupling (DCC) taking advantage succinate as an ethylene 2-carbon bridge, unique halogen dance-Zweifel sequence to rapidly access trisubstituted furan, Ni-mediated 1,6-conjugate addition, and asymmetric proton transfer.
The synthesis of quaternary carbons often requires numerous steps and complex conditions or harsh reagents that act on heavily engineered substrates. This is largely a consequence relying exclusively conventional polar-bond based retrosynthetic disconnections in turn require multiple functional group interconversions, redox manipulations, protecting chemistry. In fact, the presence center even seemingly trivial structures can dominate practitioner's entire plan (referred to by Corey as...
The synthesis of quaternary carbons often requires numerous steps and complex conditions or harsh reagents that act on heavily engineered substrates. This is largely a consequence relying exclusively conventional polar-bond based retrosynthetic disconnections in turn require multiple functional group interconversions, redox manipulations, protecting chemistry. In fact, the presence center even seemingly trivial structures can dominate practitioner's entire plan (referred to by Corey as...
Quantitative structure activity relationship (QSAR) analysis of 1, 2-disubstituted benzimidazoles IMPDH inhibitors was studied for their antibacterial activity. The 2D QSAR model developed using molecular suite (VLife MDS 4.3.1) on a set 38 molecules. Multiple Linear Regression (MLR) implemented building robust with various variable selection methods. generated emphasized that electronic, spatial, lipophilic and structural parameters play an important role in binding benzimidazole...