A5019242229- Cellular Mechanics and Interactions
- Force Microscopy Techniques and Applications
- Additive Manufacturing Materials and Processes
- Blood properties and coagulation
- Titanium Alloys Microstructure and Properties
- Microtubule and mitosis dynamics
- Elasticity and Material Modeling
- Respiratory Support and Mechanisms
- Material Dynamics and Properties
- Inhalation and Respiratory Drug Delivery
- Advanced Thermodynamics and Statistical Mechanics
- Advanced Fluorescence Microscopy Techniques
- Connective Tissue Growth Factor Research
- Tendon Structure and Treatment
- Machine Learning in Materials Science
- Ultrasound and Hyperthermia Applications
- Manufacturing Process and Optimization
- Advanced Materials and Mechanics
- Erythrocyte Function and Pathophysiology
- Quantum Electrodynamics and Casimir Effect
- Polymer crystallization and properties
- Mechanical and Optical Resonators
- Protein Structure and Dynamics
- High Entropy Alloys Studies
- Polysaccharides Composition and Applications
Technical University of Munich
2013-2022
Lawrence Livermore National Laboratory
2019
Google (United States)
2015-2016
We present a theoretical and computational analysis of the rheology networks made up bundles semiflexible filaments bound by transient cross-linkers. Such systems are ubiquitous in cytoskeleton can be formed vitro using filamentous actin various find that their high-frequency is characterized scaling behavior quite distinct from well-studied single filaments. This regime understood theoretically terms length-scale-dependent bending modulus for bundles. Next, we observe new dissipative...
Inhaled therapeutics have high potential for the treatment of chronic respiratory diseases unmet medical need, such as idiopathic pulmonary fibrosis (IPF). Preclinical and early clinical evidence show that cellular communication network factor 2 (CCN2), previously called connective tissue growth (CTGF), is a promising target IPF. In recent phase 3 trials, however, systemic CCN2 inhibition failed to demonstrate clinically meaningful benefit. Here, we present preclinical profile inhaled...
We present the determination by numerical simulation of equilibrium phase diagram solutions semi-flexible polymers with linker molecules. At low concentrations solution forms an isotropic gel phase. higher we encounter —depending on properties molecules— bundle phases, liquid-crystalline mesophases broken bond-orientational order that had been predicted analytical theories, and in addition a novel state: cluster Equilibrium condensation appears to be controlled entropy. The results are...
Abstract The elasto-plastic material behavior, strength and failure modes of metals fabricated by additive manufacturing technologies are significantly determined the underlying process-specific microstructure evolution. In this work a novel physics-based data-supported phenomenological model for Ti-6Al-4V is proposed that suitable part-scale simulation laser powder bed fusion processes. predicts spatially homogenized phase fractions most relevant microstructural species, namely stable...
Abstract Background Even an ultraprotective ventilation strategy in severe acute respiratory distress syndrome (ARDS) patients treated with extracorporeal membrane oxygenation (ECMO) might induce ventilator-induced lung injury and apneic the sole application of positive end-expiratory pressure may, therefore, be alternative strategy. We, compared effects on oxygenation, oxygen delivery, system mechanics, hemodynamics, strain, air distribution recruitment parenchyma ARDS ECMO. Methods In a...
Actin binding proteins (ABPs) not only set the structure of actin filament assemblies but also mediate frequency-dependent viscoelastic moduli cross-linked and bundled networks. Point mutations in domain those ABPs can tune association dissociation dynamics actin/ABP bond thus modulate network mechanics both linear non-linear response regime. We here demonstrate how exchange a single charged amino acid ABP fascin triggers such modulation rheology. Whereas overall bundle networks is...
The eukaryotic cytoskeleton is a protein fibre network mainly consisting of the semi-flexible biopolymer F-actin, microtubules and intermediate filaments. It well known to exhibit pronounced structural polymorphism, which enables intracellular processes such as cell adhesion, motility division. We present computational study on cross-linked networks polymers, offers detailed analysis structure phase transitions from one morphology another. elaborate morphological differences, their...
Fluctuation-induced interactions are an important organizing principle in a variety of soft matter systems. We investigate the role fluctuation-based or thermal Casimir between cross linkers semiflexible network. One finds that, by integrating out polymer degrees freedom, there is attractive logarithmic potential nearest-neighbor bundle, with significantly weaker next-nearest-neighbor interaction. Here we show that one-dimensional gas these strongly interacting equilibrium source unbound...
The big crux with drug delivery to human lungs is that the delivered dose at local site of action unpredictable and very difficult measure, even a posteriori. It highly subject-specific as it depends on lung morphology, disease, breathing, aerosol characteristics. Given these challenges, computational approaches have shown potential, but so far failed due fundamental methodical limitations. We present validate novel in silico model enables prediction deposition throughout entire lung. Its...
Molecular motors are proteins that excessively increase the efficiency of subcellular transport processes. They allow for cell division, nutrient and even macroscopic muscle movement. In order to understand effect in large biopolymer networks, e.g. cytoskeleton, we require a suitable model molecular motor. this contribution, present such based on geometrically exact beam finite-element formulation. We discuss numerical non-processive motor as myosin II, which interacts with actin filaments....
Motivated by the observation of storage excess elastic free energy, prestress, in cross-linked semiflexible networks, we consider problem conformational statistics a single polymer quenched random potential. The potential, which represents effect cross-linking to other filaments, is assumed have finite correlation length ξ and mean strength V_{0}. We examine statistical distribution curvature filament with thermal persistence ℓ_{P} L_{0} limit ℓ_{P}≫L_{0}. compare our theoretical predictions...
Received 14 July 2014DOI:https://doi.org/10.1103/PhysRevLett.113.049901© 2014 American Physical Society
The choice of lung protective ventilation settings for mechanical has a considerable impact on patient outcome, yet identifying optimal ventilatory individual patients remains highly challenging due to the inherent inter- and intra-patient pathophysiological variability. In this validation study, we demonstrate that physics-based computational models tailored can resolve variability, allowing us predict otherwise unknown local state pathologically affected during ventilation. For seven ARDS...
The elasto-plastic material behavior, strength and failure modes of metals fabricated by additive manufacturing technologies are significantly determined the underlying process-specific microstructure evolution. In this work a novel physics-based data-supported phenomenological model for Ti-6Al-4V is proposed that suitable part-scale simulation selective laser melting processes. predicts spatially homogenized phase fractions most relevant microstructural species, namely stable $\beta$-phase,...