A5092626278- Reproductive tract infections research
- Gut microbiota and health
- Cervical Cancer and HPV Research
- Probiotics and Fermented Foods
- Bacterial Identification and Susceptibility Testing
- Urinary Tract Infections Management
- Urological Disorders and Treatments
Harvard University
2023-2024
Abstract The human vaginal microbiota is frequently dominated by lactobacilli and transition to a more diverse community of anaerobic microbes associated with health risks. Glycogen released lysed epithelial cells believed be an important nutrient source in the vagina. However, mechanism which bacteria metabolize glycogen unclear, evidence implicating both bacterial enzymes. Here we biochemically characterize six glycogen-degrading enzymes (GDEs), all are pullanases (PulA homologues), from...
Elevated bacterial sialidase activity in the female genital tract is strongly associated with poor health outcomes including preterm birth and vaginosis (BV). These negative effects may arise from sialidase-mediated degradation of protective mucus layer cervicovaginal environment. Prior biochemical studies vaginal sialidases have focused solely on BV-associated organism Gardnerella vaginalis . Despite their implications for sexual reproductive health, other bacteria not been characterized....
ABSTRACT Bacterial vaginosis (BV) is a polymicrobial infection of the female reproductive tract. BV characterized by replacement health-associated Lactobacillus species diverse anerobic bacteria, including well-known Gardnerella vaginalis. Prevotella timonensis, and bivia are anerobes that found in significant number patients, but their contributions to disease process remain be determined. Defining characteristics overgrowth adherence mucosal surface increased activity mucin-degrading...
Abstract Bacterial vaginosis (BV) is a polymicrobial infection of the female reproductive tract (FRT). BV characterized by replacement health-associated Lactobacillus species diverse anaerobic bacteria, including well-known Gardnerella vaginalis . Prevotella timonensis and bivia are anaerobes that found in significant percentage patients, but their pathogenic properties yet to be determined. Defining characteristics overgrowth adherence mucosal surface increased activity mucin-degrading...
Abstract Elevated bacterial sialidase activity in the female genital tract is strongly associated with poor health outcomes including preterm birth and vaginosis. These negative effects may arise from sialidase-mediated degradation of protective mucus layer cervicovaginal environment. Prior biochemical studies vaginal sialidases have focused solely on vaginosis-associated organism Gardnerella vaginalis . Despite their implications for sexual reproductive health, other bacteria not been...
The healthy human vaginal microbiota is generally dominated by lactobacilli, and the transition to a more diverse community of anaerobic microbes associated with health risks. Glycogen released lysed epithelial cells believed be an important nutrient source in this environment. However, mechanism which bacteria metabolize glycogen unclear, evidence implicating both microbial enzymes. Here, we biochemically characterize six glycogen-degrading enzymes (GDEs) from that support growth...