A5011433584- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- CAR-T cell therapy research
- Mathematical Biology Tumor Growth
- Single-cell and spatial transcriptomics
- Renal and related cancers
- Immune Cell Function and Interaction
- Anesthesia and Pain Management
- Immunotherapy and Immune Responses
- Anesthesia and Sedative Agents
- Nausea and vomiting management
- Cancer Genomics and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- T-cell and B-cell Immunology
- Animal Genetics and Reproduction
- Anesthesia and Neurotoxicity Research
- Intraocular Surgery and Lenses
- Studies on Chitinases and Chitosanases
- Sports injuries and prevention
- Hematopoietic Stem Cell Transplantation
- Biosimilars and Bioanalytical Methods
- Nosocomial Infections in ICU
- Sports Performance and Training
- Sports and Physical Education Research
- Respiratory Support and Mechanisms
University of Helsinki
2023-2025
Helsinki University Hospital
2023-2025
Olivia Newton-John Cancer Wellness & Research Centre
2023-2024
La Trobe University
2023-2024
Cancer Research UK Clinical Trials Unit
2021-2023
University of Birmingham
2021-2023
Central University of Haryana
2023
Pain Clinic of India
2022
Institute of Medical Sciences
2020-2021
Government Medical College, Amritsar
2011-2020
Tumor-resident immune cells play a crucial role in eliciting anti-tumor immunity and immunomodulatory drug responses, yet these functions have been difficult to study without tractable models of the tumor microenvironment (TIME). Patient-derived ex vivo contain authentic resident therefore, could provide new mechanistic insights into how TIME responds or cell-directed therapies. Here, we assessed reproducibility robustness responses across two different breast cancer one renal cell...
Intraepithelial lymphocytes (IELs), including αβ and γδ T cells (T-IELs), constantly survey play a critical role in maintaining the gastrointestinal epithelium. We show that cytotoxic molecules important for defense against cancer were highly expressed by T-IELs small intestine. In contrast, abundance of colonic was dependent on microbiome displayed higher expression TCF-1/TCF7 reduced effector profile, low granzymes. Targeted deletion TCF-1 induced distinct profile colon tumor formation...
The successful use of expanded tumor-infiltrating lymphocytes (TIL) in adoptive TIL therapies has been reported, but the effects expansion, immunophenotype, function, and T cell receptor (TCR) repertoire infused products relative to tumor microenvironment (TME) are not well understood. In this study, we analyzed samples (
Renal tumours constitute about 7 per cent of all neoplasms in children. It is important to differentiate Wilms' tumour (commonest tumour) from non-Wilms' tumours. The aim this study was evaluate the immunoexpression and diagnostic role tumour-1 protein (WT1) paediatric renal tumours.A total 53 cases children (below 18 yr) who underwent nephrectomy were included retrospective study. WT1 immunostaining done using mouse monoclonal antibody (clone: 6F-H2).Of cases, 38 (72%) tumour. Non-Wilms'...
The presence of precursor to exhausted (T
Leptospirosis is a zoonotic disease caused by the spirochete of genus Leptospira with widespread distribution in tropical, subtropical and temperate zones. often confused other febrile illnesses including jaundice, dengue, malaria. Generally, underdiagnosed or misdiagnosed. Though leptospirosis curable antibiotic treatment, laboratory diagnosis specialized open to interpretation multiple kits available detect different serological markers Leptospira. Moreover, when misdiagnosed, can lead...
Background and Aims: Ambulatory surgery is continually evolving specialty in the majority of surgical procedures. Dexmedetomidine midazolam are newer adjuvants for sedation reducing dose anesthetic agents. The aim this study was to compare sedative propofol-sparing effect dexmedetomidine minor gynecological day care surgeries. Observer's Assessment Activity Sedation, additional propofol, Aldrete street fitness score were studied as primary outcomes. Hemodynamic parameters side effects...
Medications are among the second most common cause of anaphylaxis and primary in adults. The classes drugs causing antibiotics especially β-lactam nonsteroidal anti-inflammatory (NSAIDs). Diagnosis is clinically based usually straight forward. However data on epidemiology anaphylaxis, particularly profound life threatening form such as anaphylactic shock limited thought to be under-reported. In spite negative skin testing, our patient had severe reaction resulting after antibiotic...
Background: Generalized seizures have been reported following epidural anesthesia but rarely after spinal anesthesia.Aim and objective: The aim objective of our study is to create awareness about a rare possibility bupivacaine-induced generalized tonic-clonic seizures.Case description: A 19-year-old primigravida with no history any medical disease had episodes anesthesia.The patient lost consciousness was immediately intubated two seizures.Later on, she shifted the intensive care unit for...
Abstract Tissue-resident immune cells reside within the gastrointestinal tract known as intraepithelial lymphocytes (T-IELs), including αβ and γδ T-IELs. This unique population of T constantly survey are critical in maintaining epithelium. We show that T-IELs various regions have distinct features. small intestine exhibit high expression cytotoxic molecules important for cancer defense while colon distinctively regulated by transcription factor, TCF-7/TCF-1, which suppresses their effector...
ABSTRACT Tumor-resident immune cells play a crucial role in eliciting anti-tumor immunity and immunomodulatory drug responses, yet these functions have been difficult to study without tractable models of tumor microenvironment (TIME). Patient-derived ex vivo contain authentic resident therefore, could provide new mechanistic insights into how TIME responds or cell-directed therapies. Here, we assessed the reproducibility robustness responses across two different breast cancer one renal cell...
Regional anesthesia is the preferred technique for most of lower abdominal and limb surgeries as it allows patient to remain awake minimize problems associated with airway management. Hyperbaric bupivacaine 0.5%, although extensively used spinal anesthesia, has a limitation short duration. The addition fentanyl, synthetic lipophilic opioid, known prolong postoperative analgesia.We aimed study effect different doses fentanyl hyperbaric about hemodynamic changes, extent sensory motor block,...
Background:Opioids have been used with peripheral nerve blocks for its synergistic effect to enhance the postoperative analgesic effectiveness of regional block.Nalbuphine, a newer opioid an equivalence morphine, has ceiling on respiratory depression.The aim present study was evaluate nalbuphine when as adjuvant levobupivacaine 24-hour requirement after brachial plexus block (BPB).Materials and methods: Sixty adult patients either sex American Society Anesthesiologists (ASA) physical status...
Vector optimization problems are a significant extension of scalar and have wide range application in various fields economics, decision theory, game information theory optimal control theory.In this paper, unlike general subgradient methods, bundle methods gradient sampling used to solve nonsmooth vector which include scalarization approach, method without usual approached is proposed for minimizing non-differentiable convex function works directly with vector-valued function.A sub-gradient...
Ventilator associated pneumonia continues to be a cause of significant morbidity and mortality in critically ill patients.VAP is the second most common nosocomial infection intensive care units, affecting 27% all patients.In last ten years, American, Canadian, European Irish scientific societies have documented their evidence based guidelines on prevention VAP.The intent this article provide concise practical knowledge for bedside clinicians ICU aid VAP efforts.It also focuses controversies...
Summary Limited data exist on COVID‐19 vaccination efficacy in patients with acute myeloid leukemia and myelodysplasia excess blasts (AML/MDS‐EB2). We report results from a prospective study, PACE (Patients AML Epidemiology). 93 provided samples post‐vaccine 2 or 3 (PV2, PV3). Antibodies against SARS‐COV‐2 spike antigen were detectable all samples. Neutralization of the omicron variant was poorer than ancestral variants but improved PV3. In contrast, adequate T‐cell reactivity to protein...
<div><p>The successful use of expanded tumor-infiltrating lymphocytes (TIL) in adoptive TIL therapies has been reported, but the effects expansion, immunophenotype, function, and T cell receptor (TCR) repertoire infused products relative to tumor microenvironment (TME) are not well understood. In this study, we analyzed samples (<i>n</i> = 58) from treatment-naïve patients with renal carcinoma (RCC), “pre-rapidly expanded” TILs (pre-REP TIL, <i>n</i> 15)...
<p>Figure S2 shows representative flow gating strategies for the immunophenotyping of various sample types (tumor, healthy kidney, pre-REP TILs and REP TILs), as well co-culture assays.</p>
<p>Figure S3 shows representative gating strategies for the immune subset populations and T-cell subtypes healthy kidney, tumor, pre-REP TIL REP samples.</p>