A5079405748- Neurological disorders and treatments
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Treatment of Major Depression
- Obsessive-Compulsive Spectrum Disorders
- Ultrasound and Hyperthermia Applications
- Neuroscience and Neural Engineering
- bioluminescence and chemiluminescence research
- Urinary Bladder and Prostate Research
- Optical Imaging and Spectroscopy Techniques
- Transcranial Magnetic Stimulation Studies
- Eating Disorders and Behaviors
- Neuroscience and Neuropharmacology Research
University of Southern California
2022-2024
Neurological Surgery
2022-2024
Oxford University Press (United Kingdom)
2020
INTRODUCTION: Neurogenic bladder dysfunction secondary to spinal cord injuries (SCI) significantly decreases quality of life and predisposes patients severe sequelae, such as urinary tract infections septicemia. Spinal cord-machine interface (SCMI) is a promising approach restore functions. In this study, we fabricated integrated planar microelectrode arrays (MEA) for the detection axonal compound action potentials (CAPs). This enabled recording signals corresponding filling volume, an...
Introduction Both ketamine (KET) and medial prefrontal cortex (mPFC) deep brain stimulation (DBS) are emerging therapies for treatment-resistant depression, yet our understanding of their electrophysiological mechanisms biomarkers is incomplete. This study investigates aperiodic periodic spectral parameters, the signal complexity measure sample entropy, within mPFC local field potentials (LFP) in a chronic corticosterone (CORT) depression model after and/or DBS. Methods Male rats were...
Few treatments exist for the cognitive symptoms of schizophrenia. Pharmacological agents resulting in glutamate N-methyl-d-aspartate (NMDA) receptor hypofunction, such as MK-801, mimic many these and disrupt neural activity. Recent evidence suggests that deep brain stimulation (DBS) medial septal nucleus (MSN) can modulate prefrontal cortex (mPFC) hippocampal activity improve spatial memory. Here, we examine effects acute MK-801 administration on oscillatory within septohippocampal circuit...
INTRODUCTION: Alzheimer’s disease (AD) remains among the most prolific neurodegenerative disorders. The pathogenesis is result, in part, of aberrant cerebral circuitry; particular, mesolimbic-septohippocampal circuit and its associated medial septal nucleus (MSN). Interestingly, administration theta stimulation via deep brain (DBS) to MSN has been demonstrated increase hippocampal oscillations, which are critical role hippocampus learning memory. Recently, functional ultrasound imaging...
Zepeda, Nancy BS; Gifford, Raymond; Choi, Wooseong; Sheth, Megha; Medvidovic, Sasha; Bergosh, Matthew; Lu, Gengxi; Folz, Caroline; Lee, Darrin J MD, PhD Author Information
1 Abstract Ketamine and medial prefrontal cortex (mPFC) deep brain stimulation (DBS) are emerging depression treatments, however their mechanisms efficacy biomarkers have not been established. This study investigates immediate long-term mPFC electrophysiological correlates of antidepressant effects, explores the effects combinatorial treatment. Local field potential electrodes were implanted into male Sprague Dawley rats, then corticosterone was administered for 21 days, except in control...