A5034494156- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Stress Responses and Cortisol
- Parkinson's Disease Mechanisms and Treatments
- Treatment of Major Depression
- Tryptophan and brain disorders
- EEG and Brain-Computer Interfaces
- Sleep and Wakefulness Research
- Memory and Neural Mechanisms
- Neuroscience and Neural Engineering
- Neurobiology and Insect Physiology Research
- Autism Spectrum Disorder Research
- Digestive system and related health
- Schizophrenia research and treatment
- Optical Imaging and Spectroscopy Techniques
- Nuclear Receptors and Signaling
- 14-3-3 protein interactions
- Neuroscience and Music Perception
- Neuroendocrine regulation and behavior
- Neurotransmitter Receptor Influence on Behavior
- Protein Tyrosine Phosphatases
- Neural and Behavioral Psychology Studies
- Neuroinflammation and Neurodegeneration Mechanisms
University of Southern California
2022-2024
Southern California University for Professional Studies
2022-2023
Keck Hospital of USC
2023
University of Arizona
2017-2022
Amsterdam University Medical Centers
2020
University of Amsterdam
2020
Royal Netherlands Academy of Arts and Sciences
2020
Complex behaviors depend on the coordination of activities ensembles neurons and release neuromodulators such as dopamine. The mechanisms underlying are not well-understood due to a lack instrumentation for combined real-time monitoring neuromodulator large neurons. Here we describe measurement platform that allows electrophysiology from high-density electrode array dopamine dynamics carbon-fiber microelectrode. Integration these two systems was achieved through modification existing...
Hippocampal gamma and theta oscillations are associated with mnemonic navigational processes adapt to changes in the behavioral state of an animal optimize spatial information processing. It has been shown that locomotor activity modulates frequencies rats, although how age alters this modulation not well studied. Here, we examine local-field potential place cell hippocampus CA1 region young old male rats as they performed a eye-blink conditioning task across 31 d. Although mean frequency...
The specific mechanisms underlying compulsive behavior in obsessive-compulsive disorder (OCD) are unknown. It has been suggested that such compulsivity may have its origin cognitive dysfunction as impaired processing of feedback information, received after the completion goal-directed actions. signal attenuation (SA) task models a deficit animals by attenuating association strength between food reward and audiovisual (signal) presented performance an operant response. compulsive-like...
Introduction Deep brain stimulation (DBS) has shown remarkable success treating neurological and psychiatric disorders including Parkinson’s disease, essential tremor, dystonia, epilepsy, obsessive-compulsive disorder. DBS is now being explored to improve cognitive functional outcomes in other conditions, such as those characterized by reduced N-methyl-D-aspartate (NMDA) function (i.e., schizophrenia). While for movement generally involves high-frequency (>100 Hz) stimulation, there...
Introduction Both ketamine (KET) and medial prefrontal cortex (mPFC) deep brain stimulation (DBS) are emerging therapies for treatment-resistant depression, yet our understanding of their electrophysiological mechanisms biomarkers is incomplete. This study investigates aperiodic periodic spectral parameters, the signal complexity measure sample entropy, within mPFC local field potentials (LFP) in a chronic corticosterone (CORT) depression model after and/or DBS. Methods Male rats were...
Few treatments exist for the cognitive symptoms of schizophrenia. Pharmacological agents resulting in glutamate N-methyl-d-aspartate (NMDA) receptor hypofunction, such as MK-801, mimic many these and disrupt neural activity. Recent evidence suggests that deep brain stimulation (DBS) medial septal nucleus (MSN) can modulate prefrontal cortex (mPFC) hippocampal activity improve spatial memory. Here, we examine effects acute MK-801 administration on oscillatory within septohippocampal circuit...
Sleep disturbances co-occur with and precede the onset of motor symptoms in Parkinson's disease (PD). We evaluated sleep fragmentation thalamocortical spindles mice expressing p.G2019S mutation leucine-rich repeat kinase 2 (LRRK2) gene, one most common genetic forms PD. Thalamocortical are oscillatory events that occur during slow-wave involved memory consolidation. acquired data from electrocorticography, behavioral measures, a rotarod-based enrichment task 28 LRRK2-G2019S knock-in 27...
The complex and heterogeneous genetic architecture of schizophrenia inspires us to look beyond individual risk genes for therapeutic strategies target their interactive dynamics convergence. Postsynaptic NMDA receptor (NMDAR) complexes are a site such Src kinase is molecular hub NMDAR function, its protein interaction subnetwork enriched risk-genes altered associations in schizophrenia. Previously, activity was found be decreased post-mortem studies schizophrenia, contributing hypofunction....
Abstract Background Deep brain stimulation (DBS) has shown remarkable success in treating neurological and psychiatric disorders such as Parkinson’s disease, dystonia, epilepsy, obsessive-compulsive disorder. Despite this success, the underlying mechanism of action remains unknown. DBS is now being explored to improve functional outcomes other conditions, those characterized by reduced N-methyl-D-aspartate (NMDA) function (i.e. schizophrenia). While for movement requires high-frequency...
INTRODUCTION: Alzheimer’s disease (AD) remains among the most prolific neurodegenerative disorders. The pathogenesis is result, in part, of aberrant cerebral circuitry; particular, mesolimbic-septohippocampal circuit and its associated medial septal nucleus (MSN). Interestingly, administration theta stimulation via deep brain (DBS) to MSN has been demonstrated increase hippocampal oscillations, which are critical role hippocampus learning memory. Recently, functional ultrasound imaging...
1 Abstract Ketamine and medial prefrontal cortex (mPFC) deep brain stimulation (DBS) are emerging depression treatments, however their mechanisms efficacy biomarkers have not been established. This study investigates immediate long-term mPFC electrophysiological correlates of antidepressant effects, explores the effects combinatorial treatment. Local field potential electrodes were implanted into male Sprague Dawley rats, then corticosterone was administered for 21 days, except in control...
While most cases of Parkinson’s disease are idiopathic, meaning unknown origin, in 10% cases, a genetic link has been identified. Of these, the common is G2019S mutation leucine‐rich repeating kinase 2 (LRRK2) gene. Investigation into this could prove useful not only for those with LRRK2 Parkinson’s, but idiopathic as well. Genetic mouse models important translational research, despite increasingly large number studies on these animals, few have identified reliable phenotype. In study, we...