A5105103678- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Chemical Reactions and Isotopes
- Radiopharmaceutical Chemistry and Applications
- Atomic and Subatomic Physics Research
- Functional Brain Connectivity Studies
- Advanced NMR Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Lanthanide and Transition Metal Complexes
- EEG and Brain-Computer Interfaces
University Medical Center Utrecht
2024-2025
ABSTRACT Glutamate (Glu) is the major excitatory neurotransmitter in central nervous system. The measurement of Glu/glutamine (Gln) neurotransmitters brain provides valuable insights into dynamic aspects neuroenergetics and cycles can be accomplished through detection 13 C‐labeling Glu Gln during administration C‐labeled glucose. Our goal to evaluate reproducibility selective proton‐observed, carbon‐edited (selPOCE) MRS at 7 T for human brain. Data three healthy participants, who were...
Deuterium metabolic imaging (DMI) is an innovative, noninvasive MR method conducted after administration of 2H-labeled substrates. DMI [6,6'-2H2]glucose consumption has been used to investigate brain processes, but the impact different doses on data not well known. To three for in human at 7 T. Prospective. Six healthy participants (age: 28 ± 8 years, male/female: 3/3). T, 3D 2H free-induction-decay (FID)-magnetic resonance spectroscopic (MRSI) sequence. Three subjects received two (0.25...
The aim of this study is to assess the reproducibility a selective proton-observed, carbon-edited (selPOCE) MRS sequences for detection glutamate/glutamine cycling at 7T in healthy participants. Participants were scanned twice while undergoing [U-13C] glucose infusion. time course Glu C45 and Gln labeling similar test-retest measurements. This supports application future studies on measuring neuroenergetics neurotransmitter cycling.
Motivation: Deuterium metabolic imaging (DMI) is used to study processes, but the effect of varying substrate doses on DMI data in brain not yet knownGoal(s): Comparing different aims reduce cost, while still achieving sufficient sensitivity for DMIApproach: Three healthy participants received [6,6'-2H2]glucose two occasions and underwent dynamic 7T scansResults: In 120-minutes after ingesting , there no clear difference signal 2H-glucose/2H-Glx between 0. 50-0.75g/kg doses. However, was an...
Motivation: To examine the impact of 2-hour glucose infusion on neuronal activity, potentially advancing our understanding diseases such as diabetes and their regulation intake, thermogenesis, neuroendocrine system. Goal(s): Determining whether prolonged affects activity measured using rsfMRI at 7T. Approach: High resolution resting-state (rsfMRI) were acquired before directly after in 9 healthy adult subjects. Neuronal fluctuations characterized Fourier-based spectral analysis. Results: In...