A5039622687- Respiratory viral infections research
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- Pneumonia and Respiratory Infections
- Clostridium difficile and Clostridium perfringens research
- Viral gastroenteritis research and epidemiology
- COVID-19 diagnosis using AI
- Intensive Care Unit Cognitive Disorders
- Infant Nutrition and Health
- Vector-borne infectious diseases
- Fungal Infections and Studies
- Respiratory Support and Mechanisms
- Child Nutrition and Water Access
- Neonatal Respiratory Health Research
- Escherichia coli research studies
- Diabetes Treatment and Management
- Vector-Borne Animal Diseases
- Coronary Artery Anomalies
- Breastfeeding Practices and Influences
- Mosquito-borne diseases and control
- Traumatic Brain Injury and Neurovascular Disturbances
- Long-Term Effects of COVID-19
- Kawasaki Disease and Coronary Complications
- Mechanical Circulatory Support Devices
Hampshire Hospitals NHS Foundation Trust
2025
National Health Service
2025
Riley Hospital for Children
2024
Indiana University Health
2024
Indiana University – Purdue University Indianapolis
2024
University Hospitals Bristol NHS Foundation Trust
2024
University Hospitals Bristol and Weston NHS Foundation Trust
2024
University of Southampton
2015-2023
University Hospital Southampton NHS Foundation Trust
2020-2023
NIHR Southampton Biomedical Research Centre
2021-2023
The seven-valent pneumococcal conjugate vaccine (PCV7) was added to the UK national immunisation programme in September 2006. PCV13 replaced PCV7 April 2010. As carriage precedes disease cases this study collected carried pneumococci from children each winter 2006/7 2010/11 over PCV introduction. Conventional microbiology and whole genome sequencing were utilised characterise strains. Overall prevalence of remained stable. Vaccine serotypes (VT) decreased (p<0.0001) with concomitant...
BackgroundTick-borne encephalitis virus (TBEV) is a flavivirus spread by ticks and can cause tick-borne (TBE) in humans. Previously, TBE has been reported returning travellers the United Kingdom (UK), but 2019 2020, two probable cases of acquired UK were identified.AimThe aim this study was to investigate between 2015 2023, describing incidence, place mode acquisition diagnostic process.MethodsA retrospective review possible, confirmed diagnosed Rare Imported Pathogens Laboratory (RIPL)...
Abstract Objectives: Patients presenting to hospital with suspected coronavirus disease 2019 (COVID-19), based on clinical symptoms, are routinely placed in a cohort together until polymerase chain reaction (PCR) test results available. This procedure leads delays transfers definitive areas and high nosocomial transmission rates. FebriDx is finger-prick point-of-care (PoCT) that detects an antiviral host response has negative predictive value for COVID-19. We sought determine the impact of...
Objectives Previous studies have suggested that SARS-CoV-2 viral load, measured on upper respiratory tract samples at presentation to hospital using PCR Cycle threshold (Ct) value, has prognostic utility. However, these not comprehensively adjusted for factors known be intimately related load. We aimed evaluate the association between Ct value admission and patient outcome whilst adjusting carefully covariates.Methods evaluated outcomes of ICU death, in patients hospitalised during first...
RT-PCR has suboptimal sensitivity for the diagnosis of COVID-19. A composite reference standard comprising plus radiological and clinical features been recommended diagnostic accuracy studies. The FebriDx finger prick point-of-care test detects an antiviral host response protein (MxA) in 10 min. We evaluated compared to a standard.Adults presenting hospital with suspected COVID-19 were tested by RT-PCR. was used classify patients as having based on positivity, or negativity findings other...
Abstract Background Antibiotics are overused in patients hospitalized with acute respiratory illness (ARI). Diagnostic uncertainty regarding microbial etiology contributes to this practice and so a host response test that can distinguish between viral bacterial infection has the potential reduce unnecessary antibiotic use. The FebriDx is low cost, rapid, POCT uses fingerpick blood samples but not been evaluated adults ARI. Methods We took from adult ARI, during influenza season, tested them...
Background Influenza infections often remain undiagnosed in patients admitted to hospital due lack of routine testing. When tested for, the diagnosis and treatment influenza are delayed slow turnaround times centralised laboratory PCR Newer molecular systems, have comparable accuracy testing, can generate a result under 1 hour, making them potentially deployable as point-of-care tests (POCTs). High-quality evidence for impact POCT on clinical outcomes is, however, currently lacking. This...
Background: The scale of the 2022 global monkeypox outbreak has been unprecedented. In under six-months, non-endemic countries have reported over 67,000 cases a disease that had previously rare outside Africa. Mortality as but hospitalisation relatively common. We aimed to describe clinical and laboratory characteristics outcomes individuals hospitalised with associated complications, including tecovirimat recipients. Methods: Sixteen hospitals from Specialist High Consequence Infectious...
Aspergillus vertebral osteomyelitis causing deformity in immunocompetent patients is uncommon. We describe a previously healthy 68-year-old male who was referred after 2 years of lower thoracic back pain and gibbus. His inflammatory markers HIV test were normal. Imaging demonstrated bony destruction T12/L1 L2 with collapse. Following inconclusive CT-guided biopsy, he underwent reconstructive spinal surgery. Histopathology showed fungi fumigatus cultured. He treated isavuconazole 200 mg once...
Abstract Background Adults hospitalised with diarrhoea are routinely isolated as an infection control measure, but many have non-infectious etiology. Side room facilities a limited resource in hospitals. Routine laboratory testing takes several days to generate results rapid molecular platforms can test comprehensively for GI pathogens and result 1 hour, making them deployable point-of-care tests (POCT). POCT could reduce unnecessary isolation facility use addition other benefits. Methods In...
Enteral feeding pump systems deliver decreased amounts of macronutrients in human milk to neonates. This study determined the macronutrient loss associated with a bottle-feeding system and effect manually mixing during extended feeds. Macronutrient content from samples donor was analyzed after simulated feeds system, using analyzer. Simulations were repeated manual bottle every 30 min feeding. The percentage baseline calculated, one-sample t tests analysis variance compared duration on...
<h3>Introduction</h3> Patients presenting to hospital with diarrhoea are routinely isolated as an infection control measure whilst awaiting results of laboratory stool tests which typically take several days. Novel rapid molecular testing platforms, test comprehensively for gastrointestinal (GI) pathogens, generate a result in 1 hour, making them potentially deployable point-of-care (POCT). Their use may therefore rationalise the isolation facilities. <h3>Methods</h3> In this ongoing...
Abstract Background The diagnosis of Influenza in hospitalised patients is delayed due to long turnaround times laboratory testing, leading inappropriate and late antiviral isolation facility use. Molecular point-of-care test (mPOCT) are highly accurate, easy use generate results under 1 hour but high quality evidence for their clinical impact lacking. Methods In this multicentre, randomised controlled trial we enrolled adults with acute respiratory illness during influenza seasons. Patients...