A5112106273- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Computational Drug Discovery Methods
- Traditional Chinese Medicine Analysis
- Plant-based Medicinal Research
- Beetle Biology and Toxicology Studies
Hubei Zhongshan Hospital
2025
Wuhan University
2025
Jianghan University
2025
BioCryst Pharmaceuticals (United States)
2006-2016
ABSTRACT Tripterygium glycosides (TGs), the primary active components of wilfordii , have demonstrated therapeutic efficacy in treating diabetic kidney disease (DKD). However, precise mechanisms underlying their action remain elusive, limiting full realization medicinal potential. This study employed serum metabolomics based on liquid chromatography–mass spectrometry (LC‐MS) analysis to elucidate by which TGs combat DKD. We evaluated protective effects DKD following treatment. Serum samples...
Abstract Background Avoralstat is a potent small‐molecule oral plasma kallikrein inhibitor under development for treatment of hereditary angioedema (HAE). This first‐in‐human study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics avoralstat. Methods double‐blind, placebo‐controlled, ascending‐dose cohort trial avoralstat single doses 50, 125, 250, 500, 1000 mg multiple up to 2400 daily (100, 200, 400, 800 every 8 h [q8 h] 7 days). Results ( n = 71) was generally...
Abstract To explore the anti-tumor effects of Radix Astragali on hypopharyngeal carcinoma and its mechanism. We have bioinformatically analyzed potential targets predicted molecular mechanism treating carcinoma. The binding process hub that could prolong survival time cancer patients with was simulated by docking. results showed 17 out 36 effectively improve 5-year rate patients. acts regulating a signaling network formed connecting multiple pathways is expected to become drug for prolonging...