Type 2 diabetic osteoporosis (T2DOP) is a common complication in patients that seriously affects their health and quality of life. The pathogenesis T2DOP complex, there are no targeted governance means modern medicine. Citri Reticulatae Pericarpium (CRP) traditional Chinese medicine has long history been used the treatment diseases. However, molecular mechanism for CRP not clear. Therefore, this study aimed to explore underlying mechanisms by using network pharmacology modeling techniques....

Data-driven fault diagnosis approaches have been widely adopted due to their persuasive performance. However, data are always insufficient develop effective models in real manufacturing scenarios. Despite numerous that offered mitigate the negative effects of data, most challenging issue lies how break down silos enlarge volume while preserving privacy. To address this issue, a vertical federated learning (FL) model, privacy-preserving boosting tree, has developed for collaborative...

Physical fatigue (peripheral fatigue), which affects a considerable portion of the world population, is decline in ability muscle fibers to contract effectively due alterations regulatory processes action potentials. However, it lacks an efficacious therapeutic intervention. The present study explored bioactive compounds and mechanism Citrus reticulata peel (CR-P) treating physical by utilizing network pharmacology (NP), molecular docking, simulation-based dynamics (MD). ingredients CR-P...

Slow oxidative myofibers play an important role in improving muscle endurance performance and maintaining body energy homeostasis. However, the targets means to regulate slow proportion remain unknown. Here, we show that tangeretin (TG), a natural polymethoxylated flavone, significantly activates myofibers-related gene expression increases type I proportion, resulting improved aerobic metabolism mice. Proteomics, molecular dynamics, cellular thermal shift assay (CETSA) drug affinity...

As solution-processed hybrid quantum dot light-emitting diodes (QLEDs), they may undergo a positive ageing process to improve their performance. It is highly desirable investigate the treatment and further use this effect regulate performance of device. Under different periods, we analyze how CdSe/ZnxCd1–xSe/ZnSeyS1–y core/shell (QD)–ZnMgO interface possible reactions between QD, ZnMgO, Al electrode can affect device via ageing. The Kelvin probe measurements indicate reduction in energy...

The impact of volatile organic compounds (VOCs) on type 2 diabetes (T2D) among older adults is unknown. multiple linear regression model and the binary logistic were used to evaluate relationships between mVOCs glucose homeostasis/T2D, respectively. Among 19 mVOCs, higher levels urinary N-acetyl-S-(2-hydroxypropyl)-L-cysteine (2HPMA, compound CID:44146439) (HPMMA, CID:107774684) significantly associated with odds T2D (OR = 1.16, 95% confidence interval [CI]:1.01–1.34 for 2HPMA; OR 1.27,...

Sarcopenia is a systemic medical disorder characterized by gradual decline in muscular strength, function, and skeletal muscle mass. Currently, there no medication specifically approved for the treatment of this condition. Therefore, identification new pharmacological targets may offer opportunities development novel therapeutic strategies. The current silico study investigated active ingredients mode action

In this paper, we survey TCP/IP protocol processing mechanisms for high-speed networks and investigate typical of researches published in the literature to seek some enhanced strategies improving offload engines (TOEs) embedded networking based on gigabit or ten-gigabit Ethernet. our study, overheads are pointed out, a few important techniques treating these described detail. To achieve high throughput during heavy traffic load low latency light medium urgent data flow, propose an...

Bayberry is known to be a rich source of natural flavonoids and has been reported have various health-promoting abilities. However, its function on regulating skeletal muscle fiber type remains unclear. This study examined whether bayberry extract affects by promoting fast myofiber formation, as well the potential molecular mechanism. After eight weeks, "Biqi" (BBE) groups mice displayed markedly enhanced grip strength improved metabolic rate compared control group mice. BBE also...

Abstract In response to the challenge of multiple fault types and complex diagnostic criteria in bearing diagnosis, a case reasoning method based on ensemble learning is proposed. The approach utilizes Case-Based Reasoning (CBR) construct library for vibration-based features rolling bearings perform diagnosis. Moreover, addressing issue determining optimal feature weight ratios when retrieving similar cases traditional methods, Random Forest algorithm combined with Bayesian Optimization...

While the regulating mechanisms of slow myofibers have been gradually explored, there are currently a lack effective means to increase proportion. Here, we showed that luteolin could markedly improve endurance exercise performance and body oxygen consumption mice, activate aerobic enzyme activity related genes proteins expression in mice's skeletal muscle. Meanwhile, folliculin (FLCN)-AMP-activated protein kinase (AMPK) -peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α)...

Quadrotors are widely employed across various domains, yet the conventional type faces limitations due to underactuation, where attitude control is closely tied positional adjustments. In contrast, quadrotors equipped with tiltable rotors offer overactuation, empowering them track both position and trajectories. However, nonlinear dynamics of drone body sluggish response tilting servos pose challenges for cascade controllers. this study, we propose a methodology tilting-rotor based on model...

Abstract Objectives Caveolin-3 (Cav-3) plays a pivotal role in maintaining skeletal muscle mass and function. Mutations or deletions of Cav-3 can result the development various forms myopathy, which affect integrity repair capacity fiber membranes. However, potential effect on myofiber type composition remains unclear. Methods To investigate strength running capacity, we examined grip force test low/high-speed test. Oxidative glycolytic myofiber-related genes, proteins, were measured to...

The aim of this didactic article is to describe the implementation a clinical outcomes registry within setting for musculoskeletal regenerative medicine. A patient-centred registry, designed and implemented into practice clinic specializing in medicine.A focus on patient at all levels journey was established monitor continually improve care. diagnosis, treatment pathologies shoulder, elbow, hip, knee, foot spine presenting clinic. Specifically, surveillance, tracking, reporting efficacy...

In the complex unstructured road, mobile robots' ability to resist overturning is crucial. this paper, a tracked robot with passive deformation developed based on request of environment movement. The can improve stability and by adaptive mechanisms. A comprehensive judge was made tilting standard method Normalized Dynamic Energy Stability Margin index. dynamic road disturbance inertia force analyzed simulated. Theoretical analysis simulation research offer reference for application design...

Large-scale UAV switching formation tracking control has been widely applied in many fields such as search and rescue, cooperative transportation, light shows. In order to optimize the performance reduce computational burden of system, this study proposes an event-triggered optimal controller for discrete-time large-scale systems (UASs). And decision - framework is completed by introducing Hungarian algorithm actor-critic neural networks (NNs) implementation. Finally, a mixed reality...

Autonomous flight in unknown environments requires precise planning for both the spatial and temporal profiles of trajectories, which generally involves nonconvex optimization, leading to high time costs susceptibility local optima. To address these limitations, we introduce Learning-Initialized Trajectory Planner (LIT-Planner), a novel approach that guides optimization using Neural Network (NN) provide initial values. We first leverage spatial-temporal with batch sampling generate training...

In this paper, the concepts and principles of radio frequency identification (RFID) technology, ultra-high (UHF RFID) (UHF) tags were explained. The military food sensory simulation experimental platform integrated with software hardware was designed built, performance UHF RFID metal-mountable common compared by two ways stacking tunneling.