A5101769288- Microfluidic and Capillary Electrophoresis Applications
- Microfluidic and Bio-sensing Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- 3D Printing in Biomedical Research
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Aquaculture disease management and microbiota
- Porphyrin and Phthalocyanine Chemistry
- Phagocytosis and Immune Regulation
- Chemical Reactions and Isotopes
- Renal cell carcinoma treatment
- Advanced Drug Delivery Systems
- RNA Interference and Gene Delivery
- Invertebrate Immune Response Mechanisms
- Immune Response and Inflammation
- Aquaculture Nutrition and Growth
- Nanopore and Nanochannel Transport Studies
- Tuberous Sclerosis Complex Research
- Analytical Chemistry and Chromatography
- Renal and related cancers
- Immunotherapy and Immune Responses
- Protein purification and stability
- interferon and immune responses
Huizhou Central People's Hospital
2025
Guangdong Academy of Medical Sciences
2023
Southern Medical University
2023
Guangdong Provincial People's Hospital
2023
National Taiwan Ocean University
2020
Simon Fraser University
2008-2015
National Chung Cheng University
2015
Due to the cellular heterogeneity in multidrug resistance (MDR) cell populations, positive drug effects on modulation of MDR can be obscured conventional methods, especially when only a small number cells are available. To address variations among different cells, we report new microfluidic approach study effect modulation, by investigating accumulation daunorubicin leukemia cells. We have demonstrated that same-single-cell analysis (denoted as SASCA-A) is not superior different-single-cell...
The oral microbiota is associated with neuro-psychiatric disorders. However, there presently inadequate comprehension regarding the correlation between schizophrenia and microbiota. Moreover, patients frequently exhibit poor health, potentially influencing research outcomes. Therefore, this study aims to investigate changes in health status drug-free patients. Oral samples were collected from 50 healthy controls (HCs). downstream analysis was based on Illumina sequencing of V3-V4...
The front-line treatment for adult acute myeloid leukemia (AML) is anthracycline-based combination chemotherapy. However, outcomes remain suboptimal with relapses frequently observed. Among the mechanisms of failure multidrug resistance (MDR) mediated by ABCB1, ABCC1, and ABCG2 drug-efflux transporters. Although genetic phenotypic heterogeneity between leukemic blast cells a well-recognized phenomenon, there remains minimal data on differences in MDR activity at individual cell level....
Cancer is the leading cause of human death worldwide. Although many scientists work to fight this disease, multiple drug resistance a predominant obstacle for effective cancer therapy. In drug-resistant MCF-7/ADR cells, acidic organelles with lower pH value than normal one can protonation anthracycline drugs, inducing accumulation in these organelles. study, single-walled carbon nanotubes polyethylene glycol phospholipids surface modification (PEGylated SWNTs) were utilized as near...
Background. CD47 has high levels of expression in malignant cancer cells, which binds to SIRP-α release the “don’t eat me” signal and prevents mononuclear macrophages from phagocytosing cells. Resistance drugs metastases are potential barriers for prostate endocrine therapy. Although immunotherapy tumors developed rapidly last few decades, its effectiveness treating is unsatisfactory. Prostate a high-expression level CD47. Therefore, novel approach may be provided by investigating...
A small population of cancer stem cells has been identified in a range haematopoietic and solid tumours. These retain features normal including self-renewal, pluripotency altered gene expression, might represent the cell origin these tumours (Dean et al., 2005)(Fallica 2011). The possible eradication offer revolutionary advances treatment cancer. However, are rare hard to destroy due occurrence high level multidrug resistance (MDR) proteins. Tumor carrying MDR phenotype often associated with...
A single cancer cell was isolated and captured by a microfluidic single-cell biochip. The chip made of glass fabricated standard photolithography wet etch process. Simultaneous optical observation fluorescent measurement were achieved on the cell. This using red light to observe cell; whereas green emission measured photometrically monitor drug concentration. CCD camera used image morphology. At same time, PMT detector cellular concentrations change in as decrease fluorescence intensity....
Abstract This study was to examine the immunomodulatory effects of oxytetracycline (OTC) on white shrimp Litopenaeus vannamei (Boone, 1931). Immune parameters were not suppressed by OTC treatment in haemocytes vitro . A total 96 healthy divided into four groups. Group 1 control group. 2 received 50 mg OTC/kg body weight/day. 3 g β -glucan/kg feed. 4 weight/day and g/kg -glucan. residues more highly accumulated hepatopancreas than muscle tissue during rearing period, addition -glucan...
Multidrug resistance (MDR) is a significant obstacle to effective chemotherapy many patients. Because of the overexpression one membrane protein, P-glycoprotein (P-gp), there an increased efflux chemotherapeutic drug in resistant cancer cells. The main research goal MDR study get improved intracellular retention inside So it important transport In this work, single leukemia CEM cell has been isolated and captured by microfluidic single-cell biochip for study.