Osteoarthritis (OA) is a leading cause of disability and source societal costs among older adults, especially with an increasingly obese population. However, very few published studies have investigated the burden knee hip OA due to high body mass index (BMI). Therefore, this study aimed systematically summarize trends BMI in China USA between 1990 2019.Data from Global Burden Disease Study 2019 were used estimate age-standardized prevalence, disability-adjusted life years (DALYs) rates OA,...

We invented a new method for highly efficient and specific enrichment of glycopeptides using two different nanomaterials synergistically. One is boronic-acid-functionalized Fe3O4 nanoparticles, enriching through formation cyclic boronate esters between the boronic acid groups cis–diol on glycopeptides. The other nanomaterial conventional poly(methyl methacrylate) nanobeads, which have strong adsorption toward nonglycopeptides. By optimizing proportion these materials, extremely high...

A novel, simple and template-free strategy was developed for the synthesis of uniform magnetic mesoporous TiO2 nanospindles. Unlike previous synthetic approaches which mainly involve strict control sol–gel processes, templates, or capping agents, our is based on an additional post-hydrolysis route, giving rise to with a high surface area (366 m2 g−1). After crystallization, nanospindles obtained (∼117 g−1) large pore size (∼5.4 nm), exhibited susceptibility (∼18.0 emu g−1), as well showed...

Calcium and vitamin D play important roles in bone health as essential nutrients. We explored whether serum calcium, 25(OH)D were associated with mineral density (BMD) older adults.This cross-sectional study was conducted on a sample of 4595 participants (2281 men 2314 women) aged ≥ 50 years (from to 85 years, 60.1 ± 8.7 for 62.0 9.7 from the National Health Nutrition Examination Survey (NHANES) 2001-2006. The independent variables calcium 25(OH)D. dependent variable lumbar BMD. other...

Aims: Evidence linking serum uric acid (sUA) and bone mineral density (BMD) in adolescents is very limited. To the best of our knowledge, only one report has focused on relationship between sUA BMD adolescents. Thus, this study aimed to determine association total aged 12–19 years. Methods: A cross-sectional was conducted a sample composed non-institutionalised US population from National Health Nutrition Examination Survey. Weighted multivariate linear regression models were used evaluate...

ABSTRACT Osteoporosis (OP) is a prevalent metabolic bone disease globally. Currently, the development of Traditional Chinese Medicine (TCM) resources to unblock joints, strengthen bones, and enhance muscle function regulate anti‐osteogenic anabolic metabolism thus reshape intraosseous homeostasis was an effective way alleviate OP. The F–E–D formula, comprising Fructus Psoraleae, Eucommia, Drynariae Rhizoma, has shown efficacy in treating However, its complex natural components necessitate...

Selective capture of protein C-termini is still challenging in view the lower reactivity carboxyl group relative to amino groups and difficulties site-specifically labeling on C-terminus rather than that side chains acidic acids. For highly efficient purification peptides, a novel positive enrichment approach based oxazolone chemistry has been developed this study. A bifunctional reagent containing biotin arginine was incorporated into protein. Together with streptavidin affinity strategy,...

Abstract To observe and compare the curative effect of a locking plate plus titanium cable under Guide device clavicular hook in treatment Neer type II distal clavicle fractures. A prospective cohort study was conducted to analyse clinical data 36 patients with fractures from January 2016 2019. The results were analysed. According random number method, divided into two groups: group (fixed combination plate) only). Under guidance special (for which patent obtained), group, coracoclavicular...

The experiments of total ionizing dose radiation effects on CMOS APS image sensors at the rates 50.0 and 0.2 rad(Si)/s were presented. manufactured using standard <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$0.35 - \mu \hbox{m}$</tex></formula> technology that had a typical gate-oxide thickness 7.0 nm. samples divided into two groups, with one group biased other unbiased during...

The experiments of displacement damage effects on CMOS APS image sensors induced by neutron irradiation from a nuclear reactor are presented. manufactured in the standard 0.35 μm technology. flux beams was about 1.33 × 108 n/cm2s. three samples were exposed 1 MeV equivalent-fluence 1011, 5 and 1012 n/cm2, respectively. mean dark signal (KD), spike, non-uniformity (DSNU), noise (VN), saturation output voltage (VS), dynamic range (DR) versus fluence investigated. degradation mechanisms...

C-termini of proteins often play an important role in various biological processes. The determination the protein C-terminus is crucial because it provides not only distinct functional annotation but also a way to monitor proteolysis-modified proteins. In this study, isotopic labeling approach based on oxazolone chemistry was developed achieve identification and quantification C-termini. Aminolysis reagents such as arginine selectively react with α-carboxyl group at peptide via...

A novel on-plate digestion method combined with MALDI-MS analysis is reported, using trypsin-linked dendrimer-modified carbon nanotubes (dCNTs) as the enzyme immobilization probe. Excellent performance was achieved in a short time without any complicated reduction and alkylation procedures.

Electron transfer dissociation (ETD) is a useful and complementary activation method for peptide fragmentation in mass spectrometry. However, ETD spectra typically receive relatively low score the identifications of 2+ ions. To overcome this challenge, we, first time, systematically interrogated benefits combining ion charge enhancing methods (dimethylation, guanidination, m-nitrobenzyl alcohol (m-NBA) or Lys-C digestion) differential search algorithms (Mascot, Sequest, OMSSA, pFind...

The characterization of total ionizing dose (TID) damage in COTS pinned photodiode (PPD) CMOS image sensors (CISs) is investigated. radiation experiments are carried out at a 60Co γ-ray source. CISs produced by 0.18-μm technology and the pixel architecture 8T global shutter with correlated double sampling (CDS) based on 4T PPD front end. parameters such as temporal domain, spatial spectral domain measured CIS test system EMVA 1288 standard before after irradiation. dark current, random...

Charge coupled devices (CCD) have been tested at widely differing dose rates to examine the radiation tolerance dependence on rates. The test results show a maximum of CCDs 10.2 rad(Si)/sec, slight reduction in 34.8 rad(Si)/sec and quite precipitous roll off when moving down 1 0.1 rad(Si)/sec. degradation dummy output voltages dark signal are compared 0.1,1.0,10.2 respectively. It shows that levels depend divided into two groups during <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...

Four-transistor (T) pinned photodiode (PPD) CMOS image sensors (CISs) with four-megapixel resolution using 11µm pitch high dynamic range pixel were radiated 3 MeV and 10MeV protons. The dark signal was measured pre- post-radiation, the post irradiation showing a remarkable increase. A theoretical method of distribution post-radiation is used to analyze degradation mechanisms distribution. results are in good agreement experimental results. This research would provide understanding proton...

Yb <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3+</sup> /Al -doped and /P xmlns:xlink="http://www.w3.org/1999/xlink">5+</sup> silica fibers with almost identical doping concentrations were prepared using modified chemical vapor deposition methods. A harsh experimental environment for simultaneous photo-darkening (PD) radio-darkening (RD) of an ytterbium-doped fiber (YDF) was established. The RD, PD, photo-radio-darkening (PRD) the YDF...