A5090856020- Receptor Mechanisms and Signaling
- Medication Adherence and Compliance
- Pharmacological Receptor Mechanisms and Effects
- Neuropeptides and Animal Physiology
- Health Systems, Economic Evaluations, Quality of Life
- Stress Responses and Cortisol
- Pharmaceutical Practices and Patient Outcomes
- Mobile Health and mHealth Applications
- Hormonal Regulation and Hypertension
- Blood Pressure and Hypertension Studies
- Computational Drug Discovery Methods
Thermo Fisher Scientific (United States)
2025
Rowan University
2021-2023
Background Care4Today is a digital health platform developed by Johnson & comprising patient mobile app (Care4Today Connect), care provider (HCP) portal, and an educational website. It aims to improve medication adherence; enable self-reporting of experiences; provide education; enhance connection with HCPs; facilitate data analytics learning across disease areas, including cardiovascular disease. Objective This study aimed gather feedback on Connect, specifically the coronary artery...
The corticotropin-releasing factor receptor type 1 (CRF1R), a member of class B G-protein-coupled receptors (GPCRs), is good drug target for treating depression, anxiety, and other stress-related neurodisorders. However, there no approved targeting the CRF1R to date, partly due inadequate structural information its elusive activation mechanism. Here, by use crystal structures transmembrane domain (TMD) N-terminal extracellular (ECD) as template, full-length homology model was built complexes...
Pain drugs targeting mu-opioid receptors face major addiction problems that have caused an epidemic. The delta-opioid receptor (DOR) has shown to not cause addictive effects when bound agonist. While the active conformation of DOR in complex with agonist DPI-287 been recently solved, there are still no FDA-approved agonists it, providing opportunity for structure-based virtual screening. In this study, conformational plasticity was probed using molecular dynamics (MD) simulations,...
<sec> <title>BACKGROUND</title> Care4Today is a digital health platform developed by Johnson &amp; comprising patient mobile app (Care4Today Connect), care provider (HCP) portal, and an educational website. It aims to improve medication adherence; enable self-reporting of experiences; provide education; enhance connection with HCPs; facilitate data analytics learning across disease areas, including cardiovascular disease. </sec> <title>OBJECTIVE</title> This study aimed gather feedback...
The δ-opioid receptor (DOR) is a critical pharmaceutical target for pain management. Although the high-resolution crystal structures of DOR with both agonist and antagonist have recently been solved, activation mechanism remains to be elusive. In this study, ADL5859 was docked inactive multiple microsecond molecular dynamic (MD) simulations were conducted probe mechanism. While ligand (i.e. naltrindole) maintained conformation in all three independent simulations, adopting toward active out...