A5076646038- Total Knee Arthroplasty Outcomes
- Adhesion, Friction, and Surface Interactions
- Medical Imaging and Analysis
- Knee injuries and reconstruction techniques
- NF-κB Signaling Pathways
- Nutrition and Health in Aging
- Musculoskeletal pain and rehabilitation
- Spine and Intervertebral Disc Pathology
- Frailty in Older Adults
- Osteoarthritis Treatment and Mechanisms
- Immune Response and Inflammation
- Muscle Physiology and Disorders
Huazhong University of Science and Technology
2024-2025
Tongji Hospital
2024-2025
Osteoarthritis is a chronic degenerative joint disease marked by chondrocyte senescence and extracellular matrix degradation. Vaccarin, flavonoid with anti-inflammatory antioxidant properties, has not been previously investigated for its therapeutic potential in osteoarthritis. To evaluate the of Vaccarin osteoarthritis elucidate underlying mechanisms. This study utilized vitro cultures RNA sequencing to identify relevant pathways, followed validation at genetic, protein, metabolic levels...
Intervertebral disc degeneration (IVDD) is a progressive degenerative disease influenced by various factors. Genkwanin, known anti-inflammatory flavonoid, has not been explored for its potential in IVDD management. This study aims to investigate the effects and mechanisms of genkwanin on IVDD. In vitro, cell experiments revealed that dose-dependently inhibited Interleukin-1β-induced expression levels inflammatory factors (Interleukin-6, inducible nitric oxide synthase, cyclooxygenase-2)...
Abstract Background The anterior cruciate ligament (ACL) and posterior (PCL) are important structures to maintain knee stability. present study aimed further enrich understandings of the morphology ligaments explore relationship between diameter ACL PCL. Method This collected valid MRI samples 50 male female normal right joints measured each point PCL through 3D Slicer. Results in sagittal joint was significantly different from average larger than corresponding Males females had statistical...
Cancer-associated muscle wasting is a widespread syndrome in people with cancer and characterized by weight loss atrophy, leading to increased morbidity mortality. However, the tumor-derived factors that affect development of mechanism which they act remain unknown. To address this knowledge gap, we aimed delineate differences tumor molecular characteristics (especially secretion characteristics) between patients without sarcopenia across 10 types from The Cancer Genome Atlas (TCGA). We...