A5074688628- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Phagocytosis and Immune Regulation
- Cytomegalovirus and herpesvirus research
- Immune Response and Inflammation
- IL-33, ST2, and ILC Pathways
- Antimicrobial Peptides and Activities
- Immune responses and vaccinations
- Mast cells and histamine
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Biochemical and Structural Characterization
- Bacteriophages and microbial interactions
- Escherichia coli research studies
- RNA Interference and Gene Delivery
University of Otago
2017-2025
Maurice Wilkins Centre
2025
University of Auckland
2025
Mucosal-associated invariant T (MAIT) cells can be activated via either their cell receptor (TCR), which recognizes MR1-bound pyrimidines derived from microbial riboflavin biosynthesis, or cytokines. These two modes of activation may act in concert independently, depending upon the stimulus. It is unknown, however, how MAIT responses differ with mode activation. Here, we define transcriptional and effector human CD8+ to TCR cytokine stimulation. We report that rapidly respond stimulation,...
Abstract Mucosal associated invariant T (MAIT) cells are abundant unconventional that can be stimulated either via their TCR or by innate cytokines. The MAIT cell recognises a pyrimidine ligand, derived from riboflavin synthesising bacteria, bound to MR1. In infection, bacteria not only provide the ligand but also co‐stimulatory signals, such as TLR agonists, modulate TCR‐mediated activation. Recently, type I interferons (T1‐IFNs) have been identified contributing cytokine‐mediated However,...
Antibiotic-resistant bacterial infections are a significant clinical challenge, especially when involving multiple species. Antimicrobial peptides and their synthetic analogues, peptoids, which target cell membranes as well intracellular components, offer potential solutions. We evaluated the biological activities of novel peptoids TM11-TM20, include an additional charged NLys residue, against multidrug-resistant Pseudomonas aeruginosa Staphylococcus aureus, both in vitro vivo. Building on...
Mucosal associated invariant T (MAIT) cells are anti-microbial innate-like that abundant in blood and liver. MAIT express a semi-invariant T-cell receptor (TCR) recognizes pyrimidine ligand, derived from microbial riboflavin synthesis, bound to MR1. Both liver (ld)-MAIT can be robustly stimulated via TCR or by cytokines produced during bacterial viral infection. In this study, we compared the functional transcriptomic response of human ld-MAIT signals (Escherichia coli ligand) (IL-12 +...
Mucosal-associated invariant T (MAIT) cells are unconventional cytotoxic restricted by MHC class 1 related molecule, MR1. They activated through their TCR derivatives from microbial riboflavin synthesis or independently of signalling via IL-12 and IL-18. Upon activation, MAIT upregulate molecules GrzB perforin lyse bacterially-infected cells. While cytokines act as co-stimulatory that enhance cell specific role in regulating cytotoxicity remains unresolved. We show the cytokine IL-21...
Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that abundant in mucosal tissues and the liver where they can respond rapidly to a broad range of riboflavin producing bacterial fungal pathogens. Neutrophils, which recruited early sites infection, play nonredundant role pathogen clearance crucial for controlling infection. The interaction these two cell types is poorly studied. Here, we investigated both effect neutrophils on MAIT activation activated neutrophils. We...
Abstract MAIT cells are an abundant innate-like T cell population which can be activated via either their receptor (TCR), recognizes MR1-bound pyrimidine antigens derived from microbial riboflavin biosynthesis, or cytokines, such as IL-12 and IL-18. In vivo , these two modes of activation may act in concert independently depending upon the nature inflammatory stimuli. It is unknown, however, how response differs to different activation. Here, we define transcriptional effector responses...
Abstract Mucosal associated invariant T (MAIT) cells are abundant unconventional which can be stimulated either via their cell receptor (TCR) or by innate cytokines. The MAIT TCR recognises a pyrimidine ligand, derived from riboflavin synthesising bacteria, bound to MR1. In infection, bacteria not only provide the ligand but also co-stimulatory signals, such as Toll-like agonists, that modulate TCR-mediated activation. Recently, type I interferons (T1-IFNs) have been identified contributing...
Abstract Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that abundant in mucosal tissues and the liver where they can respond rapidly to a broad range of riboflavin producing bacterial fungal pathogens. Neutrophils, which recruited early sites infection, play non-redundant role pathogen clearance crucial for controlling infection. The interaction these two cell types is poorly studied. Here, we investigated both effect neutrophils on MAIT activation activated...