A5040159675- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Antimicrobial Peptides and Activities
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Biochemical and Structural Characterization
- Synthesis and Characterization of Heterocyclic Compounds
- Chemical Reaction Mechanisms
- Respiratory viral infections research
- Carbohydrate Chemistry and Synthesis
- Monoclonal and Polyclonal Antibodies Research
- Advanced MRI Techniques and Applications
- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Synthesis and Catalytic Reactions
- Tryptophan and brain disorders
- Lipid Membrane Structure and Behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Chemical Reactions and Mechanisms
- Synthesis and Biological Evaluation
- Bacteriophages and microbial interactions
- Machine Learning in Bioinformatics
- Atomic and Subatomic Physics Research
- Lanthanide and Transition Metal Complexes
- Adenosine and Purinergic Signaling
Karlsruhe Institute of Technology
2020-2025
Stanford University
2020-2021
Karlsruhe University of Education
2020
University School
2020
Viral infections, such as those caused by Herpes Simplex Virus-1 (HSV-1) and SARS-CoV-2, affect millions of people each year. However, there are few antiviral drugs that can effectively treat these infections. The standard approach in the development involves identification a unique viral target, followed design an agent addresses target. Antimicrobial peptides (AMPs) represent novel source potential drugs. AMPs have been shown to inactivate numerous different enveloped viruses through...
Inflammation processes of the central nervous system (CNS) play a vital role in pathogenesis several neurological and psychiatric disorders like depression. These are characterized by activation glia cells, such as microglia. Clinical studies showed decrease symptoms associated with mentioned diseases after treatment anti-inflammatory drugs. Therefore, investigation novel drugs could hold substantial potential neuroinflammatory background. In this vitro study, we report effects hexacyclic...
Antibiotic-resistant bacterial infections are a significant clinical challenge, especially when involving multiple species. Antimicrobial peptides and their synthetic analogues, peptoids, which target cell membranes as well intracellular components, offer potential solutions. We evaluated the biological activities of novel peptoids TM11-TM20, include an additional charged NLys residue, against multidrug-resistant Pseudomonas aeruginosa Staphylococcus aureus, both in vitro vivo. Building on...
Viral infections, such as those caused by Herpes Simplex Virus-1 (HSV-1) and SARS-CoV-2, affect millions of people each year. However, there are few antiviral drugs that can effectively treat these infections. The standard approach in the development involves identification a unique viral target, followed design an agent addresses target. Antimicrobial peptides (AMPs) represent novel source potential drugs. AMPs have been shown to inactivate numerous different enveloped viruses through...
Peptoids, or poly-N-substituted glycines, are characterised by broad structural diversity. Compared to peptides, they less restricted in rotation and lack backbone-derived H bonding. Nevertheless, certain side chains force the peptoid backbone into distinct conformations. Designable secondary structures like helices nanosheets arise from this knowledge. Herein, we report copper-catalysed alkyne-azide cycloaddition (CuAAC) of macrocycles form innovative tube-like tricyclic peptoids, giving...
Addressing intracellular targets is a challenging task that requires potent molecular transporters capable to deliver various cargos. Herein, we report the synthesis of hydrophobic macrocycles composed both amino acids and peptoid monomers. The cyclic tetramers hexamers were assembled in modular approach using solid as well solution phase techniques. To monitor their localization, attached fluorophore Rhodamine B. Most efficiently internalized by HeLa cells revealed specific accumulation...
We describe the synthesis of so far synthetically not accessible 3,6-substituted-4,6-dihydro-3H-pyrazolo[3,4-d][1,2,3]triazines as nitrogen-rich heterocycles. The target compounds were obtained in five steps, including an amidation and a cyclative cleavage reaction key steps. introduction two side chains allowed variation pyrazolo[3,4-d][1,2,3]triazine core with commercially available building blocks, enabling extension protocol to gain other derivatives straightforwardly. Attempts...
The rise of drug resistance has become a global crisis, with >1 million deaths due to resistant bacterial infections each year. Pseudomonas aeruginosa, in particular, remains serious problem limited solutions complex mechanisms that now lead more than 32,000 multidrug-resistant (MDR) and over 2000 the U.S. annually. While emergence bacteria ominously common, identification useful new classes been past 40 years. We found potential novel therapeutic, peptide-mimetic TM5, is effective at...
The determination of the three-dimensional structure is a key step for identification new targets as well rational design bioactive compounds. Herein, we report synthesis and structural elucidation novel tetrameric macrocycles. Measurements were taken in solid solution states with help X-ray scattering NMR spectroscopy. investigations made will to find diverse applications this new, promising compound class.
Outstanding affinity and specificity are the main characteristics of peptides, rendering them interesting compounds for basic medicinal research. However, their biological applicability is limited due to fast proteolytic degradation. The use mimetic peptoids overcomes this disadvantage, though they lack stereochemical information at α-carbon. Hybrids composed amino acids peptoid monomers combine unique properties both parent classes. Rigidification backbone increases towards various targets....
Abstract The rise of drug resistance has become a global crisis, with >1 million deaths due to resistant bacterial infections each year. Pseudomonas aeruginosa, in particular, remains serious problem limited solutions complex mechanisms that now lead more than 32,000 multidrug-resistant (MDR) and over 2,000 annually. While the emergence bacteria concerningly common, identification useful new classes been past 40+ years. We found potential novel therapeutic, peptide-mimetic TM5, is...
Most therapeutic strategies for the development of antiviral agents are designed based on targets specific to each virus. We examined potential broad-spectrum activity antimicrobial peptoids (AMPs) against two different viruses. AMPs mimetics peptides, which sequence-specific N-substituted glycine oligomers, where their side chains appended backbone amide nitrogens rather than α-carbons. As a result, not proteolyzed, and have improved biostability bioavailability reduced immunogenicity...
We describe the synthesis of so far synthetically not accessible 3,6-substituted-4,6-dihydro-3H-pyrazolo[3,4-d][1,2,3]triazines as nitrogen-rich heterocycles. The target compounds were obtained in five steps, including an amidation and a cyclative cleavage reaction key steps. introduction two side-chains allowed variation pyrazolo[3,4-d][1,2,3]triazine-core with commercially available building blocks, enabling extension protocol to gain other derivatives straightforwardly. Attempts...