A5083795918- Molecular spectroscopy and chirality
- Axial and Atropisomeric Chirality Synthesis
- Catalysts for Methane Reforming
- Asymmetric Synthesis and Catalysis
- Carbohydrate Chemistry and Synthesis
- Chemical synthesis and alkaloids
- Asymmetric Hydrogenation and Catalysis
- Synthesis of Organic Compounds
- Catalysis for Biomass Conversion
Centrale Marseille
2024
Aix-Marseille Université
2024
Centre National de la Recherche Scientifique
2024
Université de Montréal
2022
Enantioselective construction of small molecules displaying a configurationally stable helical shape built on fused-tetracyclic core is daunting synthetic challenge even more pronounced when five-membered rings are incorporated in the structure. The resulting higher configurational lability strongly hampers their access, and therefore development new efficient methodologies timely highly desirable. In this context, we describe padlocking approach
Polygonapholine was isolated in 1997 from the Polygonatum alte-lobatum rhizome. Based on spectroscopic data, it assigned a structure comprising an unusual cis-2,6-disubstituted bis-aryl morpholine ring to which is attached (Z)-4-hydroxycinnamate as amide and (E)-4-hydroxycinnamate ester. Being meso compound, polygonapholine should not exhibit optical rotation reported. A total synthesis of purported alkaloid presented herein reveals discrepancies between synthetic natural product casting...