A5103179605- Advanced MRI Techniques and Applications
- Advanced NMR Techniques and Applications
- NMR spectroscopy and applications
- Atomic and Subatomic Physics Research
- Lanthanide and Transition Metal Complexes
- Neonatal and fetal brain pathology
- Multiple Sclerosis Research Studies
- MRI in cancer diagnosis
- Mitochondrial Function and Pathology
- Neuroscience of respiration and sleep
- Neurological disorders and treatments
- Vestibular and auditory disorders
- Ultrasound and Hyperthermia Applications
- Medical Imaging Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Genetic Neurodegenerative Diseases
- Neonatal Health and Biochemistry
- Functional Brain Connectivity Studies
- Systemic Sclerosis and Related Diseases
- Cardiovascular Syncope and Autonomic Disorders
- Advanced X-ray Imaging Techniques
Tulane University
2023
Hammersmith Hospital
1988-1997
Middlesex Hospital
1988-1994
University College London
1988-1994
Royal London Hospital
1994
Picker Institute Europe
1990
Middlesex University
1989
National Hospital for Neurology and Neurosurgery
1988
John Gill Technology (United Kingdom)
1988
Youngdong University
1988
The theoretical basis for the use of paramagnetic agents to enhance proton relaxation is described. Factors importance in design contrast are considered. Measurements changes T1 and T2 vitro due Gd3+-diethylenetriamine pentaacetic acid (DTPA) used predict intensity transverse magnetisation seen with different sequences magnetic resonance imaging. Gd3+-DTPA clinical cases illustrated.
Abstract The gene responsible for Huntington's disease (HD) has been located, but its action and the pathophysiology of HD remain unclear. Glutamate excitotoxicity may contribute to striatal neurodegeneration seen in HD. We used localised proton magnetic resonance spectroscopy (MRS) brain investigate five patients with early HD, one symptom‐free carrier, 14 healthy volunteers. Peak area ratios choline‐containing compounds (Cho), glutamine glutamate (Glx), N ‐acetyl moieties including...
Abstract Existing models for the contrast between one tissue and another in NMR imaging have shown that there are regions of ambiguity particularly spin‐echo sequences. This paper indicates further problems due to variations slice formation with parameters, it is necessary be very conservative assessing magnitude T 1 any system. The change shape affects appearance images due, essence, adjustments partial volume effects, some contributions signal from lesions long coming different those...
A technique for assessing brain perfusion with magnetic resonance (MR) imaging is described. This uses two spin echo sequences that are identical except the second sensitised to blood flow by use of a pair unipolar gradients on either side 180° pulse. Differences in phase between displayed sensitivity rates ±0.5, ±1, and ±2 mm/s per full scale (±π radians) deflection. The was validated measurement at these water phantom. Ten patients cerebrovascular disease, multiple sclerosis, cerebral...
Four dimensional chemical shift imaging was used to map the relative peak heights of phosphorus metabolites liver and overlying skeletal muscle a normal subject two patients. The technique provides 31P spectra localised on voxel-by-voxel basis may be valuable in mapping heterogeneous structural metabolic changes disease.
Localized 31P NMR spectroscopy was used to study the developing human liver in three neonates and one infant, all with neonatal intracranial problems, but normal function. A prominent resonance present phosphomonoester (PME) region of spectrum neonates; PME/ATP ratio 1.0 +/- 0.4 (repetition time 1 s), compared mean adult value 0.2 0.1. The saturation factor PME large, indicating that increase reflected an relative concentration. chemical shift peak (6.8 0.1) similar found brain, suggesting...
Two patients with non-Hodgkin lymphoma of the femur were examined 31P magnetic resonance spectroscopy (MRS) and proton imaging before during treatment chemotherapy. Prior to treatment, MRS tumor showed that in comparison normal skeletal muscle, phosphocreatine was reduced, phosphomonoesters (PME) phosphodiesters elevated. The spectrum became similar muscle after 40 days both cases. Following initial dose chemotherapy, an increase PME relative adenosine triphosphate observed within 48 h one...
The results of 165 clinical examinations the brain in which phase mapping was used to display susceptibility effects have been analysed. Significant changes were frequently observed when hemorrhage a primary or secondary event. A substantial fraction examinations, including those tumor, trauma, hemorrhage, and other patients, showed up 1 ppm. Spectral interpretation may be made more difficult many circumstances by effects.
Abstract This communication describes the use of a binomial pulse sequence designed from solvent suppression in proton spectroscopy to convert small frequency changes associated with field variations into significant amplitude magnetic resonance images. technique can be used demonstrate tissue susceptibility change. © 1989 Academic Press, Inc.
The carotid sinus nerve (CSN) is well known as mediating baroreflexes. However, studies of its detailed histological analysis are scant in the literature. Therefore, current anatomical study sought to better elucidate microanatomy CSN. Ten fresh frozen adult cadavers underwent dissection Then, it was harvested and submitted for immunohistochemical staining. Specimens were all shown be fibers on histology immunohistochemistry. We identified tyrosine hydroxylase positive CSN specimens. These...
Attempts at saturation by nonselective rf pulses, followed gradient spoiler are sometimes used as the basis of a method measuring T1 in magnetic resonance imaging, because this type is perceived being less affected slice shape artifact than partial methods. This note suggests that, unless care taken, assumption can be quite erroneous.