A5043508273- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Pharmacological Receptor Mechanisms and Effects
- Acute Kidney Injury Research
- Glioma Diagnosis and Treatment
- Chromosomal and Genetic Variations
- Sleep and Wakefulness Research
- Pharmaceutical studies and practices
- Brain Metastases and Treatment
Pirogov Russian National Research Medical University
2010-2024
Ministry of Health of the Russian Federation
2013-2024
Bogomolets National Medical University
2016
Vladivostok State Medical University
2010
City Clinical Hospital
2010
Antiepileptic drugs are frequently associated with a risk of adverse effects, which have an impact on the tolerability and success treatment. Patients who develop intolerable effects to discontinue treatment early after initiation or switch another antiepileptic drug. A long-term management strategy for patients such long-lasting chronic disease as epilepsy should include both effective seizure control detection drug events, ensuring prognosis, prevention minimizing side is quite important....
Many patients with epilepsy receive treatment in polytherapy. Selection of antiepileptic drugs (AEDs) for the combination should be carried out accordance principles rational polytherapy, taking into account mechanism action, pharmacokinetic (PK) and pharmacodynamic (PD) properties drugs. Along levetiracetam, gabapentin, vigabatrin pregabalin, lacosamide (LCM) shows superior PK profile rating all AED can combined any them. The goal this study was to evaluate efficacy tolerability LCM...
Sleep disorders occur twice as often in epilepsy patients compared to healthy people and have a negative impact on seizure control general quality of life. International Russian publications the effect perampanel (PER) sleep emphasise positive drug quality, daytime sleepiness architecture. Objective : evaluate PER (Fycompa®) when used an adjunct antiepileptic (AED) treatment adults. Material methods . The study included 106 aged 18 73 years with absolute predominance focal (n=96) who were...
There is a number of unsolved issues in management epilepsy associated with primary and metastatic brain tumors (BTs). In particular, no consensus approaches to treatment patients BTs have been proposed regarding use current anti-epileptic drugs (AEDs). The review presents the relevant data on epidemiology, features clinically manifested at varying stages BTs, aspects drug-drug interaction between AEDs anti-tumor agents, AED-related effects cognitive functions as well quality life BTs....
Objective: To estimate clinical course and proximal hospital outcome in group of patients with early significant increase NGAL as a marker renal tubular injury. Design Method: In our study we included 67 pts «wet-warm» ADHF, divided them to 2 groups. Gr.1 - 16 on 3 day (D3) ≥ 20% from 1st (D1), Gr.2 51 without such increase. At baseline gr.1 gr.2 had no difference other laboratory parameters. Congestion endpoints were plasma NT-pro-BNP (ELISA) mitral E/E’ (TDI) at D3 Dsc. Renal acute kidney...