A5012733271- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Neuroscience and Neuropharmacology Research
- Colorectal Cancer Surgical Treatments
- Amino Acid Enzymes and Metabolism
- HIV Research and Treatment
- Neurotransmitter Receptor Influence on Behavior
- Immunotherapy and Immune Responses
- Lung Cancer Diagnosis and Treatment
- Estrogen and related hormone effects
- Immune Cell Function and Interaction
- Mitochondrial Function and Pathology
- Nitric Oxide and Endothelin Effects
- T-cell and B-cell Immunology
- Peptidase Inhibition and Analysis
- Gastric Cancer Management and Outcomes
- Alzheimer's disease research and treatments
- Neuroendocrine regulation and behavior
- Nicotinic Acetylcholine Receptors Study
- Prenatal Substance Exposure Effects
- Oral and gingival health research
- Anorectal Disease Treatments and Outcomes
- Ion channel regulation and function
- Colorectal Cancer Treatments and Studies
- Epilepsy research and treatment
Texas Christian University
2023-2025
St James's University Hospital
2015
Nottingham University Hospitals NHS Trust
2015
Leeds Teaching Hospitals NHS Trust
2015
East Tennessee State University
2015
Tusculum College
2013
University of Arizona
2013
University of Kentucky
2005-2012
Leeds General Infirmary
2008-2011
South College
2011
Abstract Background Abdominoperineal excision (APE) for low rectal cancer is associated with higher rates of circumferential resection margin (CRM) involvement and intraoperative perforation (IOPs) than anterior tumours. This multicentre observational study was designed to confirm that extralevator APE can improve outcomes investigated the morbidity such extensive surgery. Methods Some 176 procedures from 11 European colorectal surgeons were compared 124 standard excisions one UK centre....
Previous studies have reported that as many one third of applicants misrepresent their publication record on residency or fellowship applications.To determine the incidence potentially fraudulent (or "phantom") research publications among to a colorectal surgery program.Electronic Residency Application Services applications were reviewed. All listed tabulated and checked whether they published using various search engines.Cedars-Sinai Medical Center.Applicants from 2006 2008.We searched for...
The metal binding properties of macrocyclic small molecules are a key property that drives the applications for which these ligands can be used. Pyridine-modified Py2N2 pyridinophane new class molecules, whose have not been explored. As result, Zn(II) library six pyridine-modified complexes is reported here. These results include 1H NMR, log βZn(II), and X-ray diffraction, compared to PyN3 congeners show differences in each scaffold yield markedly different exploited future applications.
Recombinant HLA-A2, HLA-B8, or HLA-B53 heavy chain produced in Escherichia coli was combined with recombinant β2-microglobulin (β2m) and a pool of randomly synthesised nonamer peptides. This mixture allowed to refold form stable major histocompatability complex (MHC) class I complexes, which were then purified by gel filtration chromatography. The peptides bound the MHC molecules subsequently eluted sequenced as pool. Peptide binding motifs for these three derived compared previously...
Neuronal adaptations that occur during chronic ethanol (EtOH) exposure have been observed to sensitize the brain excitotoxic insult withdrawal. The adenosine receptor system warrants further examination in this regard, as recent evidence has implicated involvement behavioral effects of both EtOH and
BACKGROUND This study examines the combined effect of two common genetic alterations, ERG and PTEN, in prostate carcinoma progression. METHODS Prostate tissue from 90 patients having unilateral capsular penetrating lesions, a contra-lateral organ confined second lesion, were examined by immunohistochemistry for expression TMPRSS2:ERG transformation product loss powerful phosphatase inhibiting PI3 kinase pathway. Multivariate logistic regression was carried out to analyze data. RESULTS After...
Aims UK faecal occult blood test screening has tripled the proportion of pT1 colorectal cancers. The risk metastasis is predicted by depth invasion, suggesting that access to deep lymphovascular vessels important. aim this study was quantify distribution and size submucosal vasculature, generate a novel three‐dimensional (3D) model validate findings. Methods results Thirty samples normal large bowel wall were immunostained with CD 31, vascular endothelium marker, identify vessels, which...
Data on the prognostic factors for survival in patients with locally advanced, node-negative colon cancer are limited. This study aimed to determine which might predict Dukes' B (T3 or T4, N0) cancer.One hundred and eighty (93 male; median age 75 [range, 38-96] years) consecutive who had resection of a primary (on final histopathological analysis) colonic between 1998 2003 were studied. No patient received neoadjuvant chemotherapy. Multivariate Cox regression modelling was used assess value...
Abstract: Background: Millions of Americans suffer from Alzheimer's Disease (AD), which is characterized by significant neurological impairment and an accumulation in brain tissue senile plaques consisting beta amyloid (Aβ) peptide. The hippocampus, a region primarily responsible for learning memory, appears to be particularly susceptible AD-related injury chronic alcohol abuse. Although certain risk factors AD are known, it unclear if abuse or dependence may contribute neuropathology AD....
The abundance of manganese in nature and versatility to access different oxidation states have made complexes attractive as catalysts for reactions both biology industry. Macrocyclic ligands offer the advantage substantially controlling reactivity center through electronic tuning steric constraint. Inspired by catalase enzyme, a biological catalyst disproportionation H
The continual bacterial adaptation to antibiotics creates an ongoing medical need for the development of novel therapeutics. Polypeptide deformylase (PDF) is a highly conserved enzyme, which essential viability. It has previously been shown that PDF inhibitors represent promising new area antimicrobial agents, and many best demonstrate slow, time-dependent binding. To improve our understanding mechanistic origin this inhibition, we examined in detail kinetics catalysis inhibition by several...