A5101699010- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Metal complexes synthesis and properties
- Herpesvirus Infections and Treatments
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- interferon and immune responses
- Organic Food and Agriculture
- Injury Epidemiology and Prevention
- Virus-based gene therapy research
- Animal Disease Management and Epidemiology
- Lanthanide and Transition Metal Complexes
- Hepatitis B Virus Studies
- Nanocluster Synthesis and Applications
- Agricultural Systems and Practices
- Organ Transplantation Techniques and Outcomes
- Cytomegalovirus and herpesvirus research
- Agriculture, Land Use, Rural Development
- vaccines and immunoinformatics approaches
- HIV Research and Treatment
- DNA and Nucleic Acid Chemistry
- RNA Research and Splicing
- Drug Transport and Resistance Mechanisms
Qingdao Agricultural University
2023-2024
Henan University
2018-2020
The First Affiliated Hospital, Sun Yat-sen University
2016
Sun Yat-sen University
2016
Porcine epidemic diarrhea virus (PEDV), an intestinal pathogenic coronavirus, has caused significant economic losses to the swine industry worldwide. At present, there are several treatment methods, but is still a lack of clinically effective targeted drugs, new antiviral mechanisms and drugs need be explored.In this study, we established model erastin versus ferrostatin-1 Vero cells, then detected proliferation gene expression by RT-qPCR through PEDV infection experiments.We demonstrated...
Porcine epidemic diarrhea virus (PEDV) is a highly contagious coronavirus that induces and death in neonatal piglets, resulting substantial economic losses to the global swine industry. The mechanisms of PEDV infection roles host factors are still under exploration. In this study, we used ferroptosis pathway downstream target activator (1S,3R)-RSL3 compound as starting point, combined with interactions N-acetylcysteine deferoxamine, elucidate effects series compounds on proliferation. We...
Physiological characteristics of human malignancies are increased glycolysis and overexpression glucose transporters (GLUTs). 18Flurodeoxyglucose-positron emission tomography (FDG-PET) has successfully developed as clinical modality for the diagnosis staging many cancers based on Warburg effect. To leverage this transporter mediated metabolic disparity between normal malignant cells, in current report, protected de-protected glucose, mannose, galactose, rhamnose, maltose lactose-conjugated...
Pseudorabies virus (PRV) is a herpesvirus that can infect domestic animals, such as pigs, cattle and sheep, cause fever, itching (except pigs), encephalomyelitis. In particular, the emergence of PRV variants in 2011 have resulted serious economic losses to Chinese pig industry. However, signaling pathways mediated by their related mechanisms are not fully understood.Here, we performed RNA-seq compare gene expression profiling between virulent SD2017-infected PK15 cells Bartha-K/61-infected...
Abstract Background Pseudorabies virus (PRV) causes substantial losses in the swine industry worldwide. Attenuated PRV strains with deletions of immunomodulatory genes glycoprotein E (gE), I (gI) and thymidine kinase (TK) are candidate vaccines. However, effects gE/gI/TK on PRV-host interactions not well understood. Methods To characterize impact host cells, we analyzed compared transcriptomes PK15 cells infected wild-type (SD2017), (SD2017gE/gI/TK) using RNA-sequencing. Results The...
Porcine epidemic diarrhea (PED), caused by porcine virus (PEDV), is an acute and contagious enteric disease with high mortality in sucking piglets, causing huge economic losses to swine industry. In this study, we used tandem mass tag (TMT) quantitative protein analysis investigate the proteomic changes of PK15 cells after PEDV infection, differential expression profiles were obtained at 0 h, 24 48 h infection. Overall, 6330 proteins identified total. The criteria fold change >1.5 < 0.67...