A5043213426- Neuroscience and Neural Engineering
- Cardiac electrophysiology and arrhythmias
- Pluripotent Stem Cells Research
- Cardiac Arrhythmias and Treatments
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Genomics, phytochemicals, and oxidative stress
- Photoreceptor and optogenetics research
- Blood Pressure and Hypertension Studies
- Ion channel regulation and function
- Eicosanoids and Hypertension Pharmacology
- Pharmaceutical Practices and Patient Outcomes
- Chemotherapy-induced cardiotoxicity and mitigation
- Potassium and Related Disorders
- Neuroscience and Neuropharmacology Research
- Acute Myocardial Infarction Research
- Electrochemical sensors and biosensors
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
Universität Hamburg
2022-2025
University Medical Center Hamburg-Eppendorf
2022-2025
German Centre for Cardiovascular Research
2022-2025
Istanbul University-Cerrahpaşa
2022
Transient perturbation of electrical activity is used in neuroscience to study the impact specific neuronal cell populations on brain function. Similarly, cardiomyocyte (CM) physiology can be controlled by activation artificially expressed ion channels. Pharmacologically selective actuator modules (PSAMs) are engineered ligand-gated channels that activated with small molecules. We aimed use 'inhibitory' PSAMs, (i) PSAML141F,Y115F-GlyR (PSAM-GlyR) and (ii) PSAML131G,Q139L,Y217F (ultrapotent...
Retinoic acid (RA) induces an atrial phenotype in human induced pluripotent stem cells (hiPSCs), but expression of atrium-selective currents such as the ultrarapid (IKur) and acetylcholine-stimulated K+ current is variable less than adult atrium. We suspected methodological issues systematically investigated concentration dependency RA. RA treatment increased IKur dependently from 1.1 ± 0.54 pA/pF (0 RA) to 3.8 1.1, 5.8 2.5, 12.2 4.3 at 0.01, 0.1, 1 μM, respectively. Only μM enough fully...
Optogenetic actuators are rapidly advancing tools used to control physiology in excitable cells, such as neurons and cardiomyocytes. In neuroscience, these have been either excite or inhibit neuronal activity. Cell type-targeted allowed study the function of distinct cell populations. Whereas first described cation channelrhodopsins specific populations, anion were To allow for simultaneous excitation inhibition, opsin combinations with low spectral overlap introduced. BiPOLES (Bidirectional...
Background and Objectives: Chronic kidney disease (CKD) is usually linked with polypharmacy patients are invariably at risk of complex medication regimens. The present study was designed to estimate the potential drug-drug interactions (pDDIs) through prescription patterns provided Nephrology Transplant Unit Cerrahpasa Medical Faculty patients. Materials Methods: 96 were included in study. pDDIs among every combination prescribed drug analyzed using Thomson Reuters Micromedex. Results: We...
Background: Diabetes mellitus leads to endothelial dysfunction and accumulation of oxygen radicals. Sulfasalazine-induced Nrf2 activation reduces oxidative stress in vessels. Thus, the present study, we investigated effects sulfasalazine on induced by high glucose. We also ascribed underlying mechanism involved glucose-induced dysfunction. Methods: For this experiment used 80 Wistar Albino rats thoracic aorta calculate dose response curve noradrenaline acetylcholine. Vessels were incubated...
Summary Retinoic acid (RA) induces an atrial phenotype in human induced pluripotent stem cells (hiPSC), but expression of atrium-selective currents such as the ultrarapid (I Kur ) and acetylcholine-stimulated K + current K,ACh is variable less than adult atrium. We suspected methodological issues systematically investigated concentration-dependency RA. RA treatment increased I concentration-dependently from 1.1±0.54 pA/pF (0 RA) to 3.8±1.1, 5.8±2.5 12.2±4.3 at 0.01, 0.1 1 µM, respectively....
Human induced pluripotent stem cell-derived atrial cardiomyocytes (hiPSC-aCM) could be a helpful tool to study the physiology and diseases of human atrium. To fulfil this expectation, electrophysiology hiPSC-aCM should closely resemble situation in Data on contribution slowly activating delayed rectifier currents (IKs) repolarization are lacking for both atrium hiPSC-aCM.